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DC Field | Value | Language |
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dc.contributor.author | Thillai, M | - |
dc.contributor.author | Eberhardt, C | - |
dc.contributor.author | Lewin, AM | - |
dc.contributor.author | Potiphar, L | - |
dc.contributor.author | Hingley-Wilson, S | - |
dc.contributor.author | Sridhar, S | - |
dc.contributor.author | Macintyre, J | - |
dc.contributor.author | Kon, OM | - |
dc.contributor.author | Wickremasinghe, M | - |
dc.contributor.author | Wells, A | - |
dc.contributor.author | Weeks, ME | - |
dc.contributor.author | Mitchell, D | - |
dc.contributor.author | Lalvani, A | - |
dc.date.accessioned | 2015-10-09T14:42:58Z | - |
dc.date.available | 2012-07-16 | - |
dc.date.available | 2015-10-09T14:42:58Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PLoS ONE, 7(7): e38083, (2012) | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038083 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/11463 | - |
dc.description.abstract | Background: The clinical, radiological and pathological similarities between sarcoidosis and tuberculosis can make disease differentiation challenging. A complicating factor is that some cases of sarcoidosis may be initiated by mycobacteria. We hypothesised that immunological profiling might provide insight into a possible relationship between the diseases or allow us to distinguish between them. Methods: We analysed bronchoalveolar lavage (BAL) fluid in sarcoidosis (n = 18), tuberculosis (n = 12) and healthy volunteers (n = 16). We further investigated serum samples in the same groups; sarcoidosis (n = 40), tuberculosis (n = 15) and healthy volunteers (n = 40). A cross-sectional analysis of multiple cytokine profiles was performed and data used to discriminate between samples. Results: We found that BAL profiles were indistinguishable between both diseases and significantly different from healthy volunteers. In sera, tuberculosis patients had significantly lower levels of the Th2 cytokine interleukin-4 (IL-4) than those with sarcoidosis (p = 0.004). Additional serum differences allowed us to create a linear regression model for disease differentiation (within-sample accuracy 91%, cross-validation accuracy 73%). Conclusions: These data warrant replication in independent cohorts to further develop and validate a serum cytokine signature that may be able to distinguish sarcoidosis from tuberculosis. Systemic Th2 cytokine differences between sarcoidosis and tuberculosis may also underly different disease outcomes to similar respiratory stimuli. | en_US |
dc.description.sponsorship | This work is supported by the Wellcome Trust (grant code WT085275MA) and the Medical Research Council (grant code G0801620). | en_US |
dc.language.iso | en | en_US |
dc.publisher | PLOS | en_US |
dc.subject | Sarcoidosis | en_US |
dc.subject | Multiplex cytokine analysis | en_US |
dc.subject | Tuberculosis | en_US |
dc.subject | Blood | en_US |
dc.title | Sarcoidosis and tuberculosis cytokine profiles: Indistinguishable in bronchoalveolar lavage but different in blood | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0038083 | - |
dc.relation.isPartOf | PLoS ONE | - |
pubs.issue | 7 | - |
pubs.volume | 7 | - |
Appears in Collections: | Dept of Mathematics Research Papers |
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Fulltext.pdf | 514.05 kB | Adobe PDF | View/Open |
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