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http://bura.brunel.ac.uk/handle/2438/11568
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Turro, E | - |
dc.contributor.author | Su, SY | - |
dc.contributor.author | Gonçalves, A | - |
dc.contributor.author | Coin, LJM | - |
dc.contributor.author | Richardson, S | - |
dc.contributor.author | Lewin, A | - |
dc.date.accessioned | 2015-11-09T14:02:13Z | - |
dc.date.available | 2011-02-10 | - |
dc.date.available | 2015-11-09T14:02:13Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Genome Biology, 12:R13, (2011) | en_US |
dc.identifier.issn | 1474-7596 | - |
dc.identifier.issn | 1474-760X | - |
dc.identifier.uri | http://www.genomebiology.com/2011/12/2/R13 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/11568 | - |
dc.description.abstract | We present a novel pipeline and methodology for simultaneously estimating isoform expression and allelic imbalance in diploid organisms using RNA-seq data. We achieve this by modeling the expression of haplotype-specific isoforms. If unknown, the two parental isoform sequences can be individually reconstructed. A new statistical method, MMSEQ, deconvolves the mapping of reads to multiple transcripts (isoforms or haplotype-specific isoforms). Our software can take into account non-uniform read generation and works with paired-end reads. | en_US |
dc.description.sponsorship | BBSRC grant BBG0003521 | en_US |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central | en_US |
dc.subject | Isoform level expression | en_US |
dc.subject | RNA-seq data | en_US |
dc.subject | MMSEQ | en_US |
dc.title | Haplotype and isoform specific expression estimation using multi-mapping RNA-seq reads | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1186/gb-2011-12-2-r13 | - |
dc.relation.isPartOf | Genome Biology | - |
pubs.issue | 2 | - |
pubs.volume | 12 | - |
Appears in Collections: | Dept of Mathematics Research Papers |
Files in This Item:
File | Description | Size | Format | |
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Fulltext.pdf | 3.09 MB | Adobe PDF | View/Open |
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