Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/1355
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dc.contributor.authorKoh, YKK-
dc.contributor.authorChiu, TY-
dc.contributor.authorBoobis, AR-
dc.contributor.authorCartmell, E-
dc.contributor.authorLester, JN-
dc.contributor.authorScrimshaw, MD-
dc.coverage.spatial19en
dc.date.accessioned2007-11-27T09:41:48Z-
dc.date.available2007-11-27T09:41:48Z-
dc.date.issued2007-
dc.identifier.citationJournal of Chromatography. 1173: 81–87, Nov 2007en
dc.identifier.issn0021-9673-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/1355-
dc.description.abstractThis paper discusses the requirement for, and presents an analytical procedure for, the determination of four unconjugated steroid hormones and a conjugated steroid (estrone-3-sulfate) in wastewaters. The method quantifies the steroids by LC/MS/MS following solid phase extraction and a two stage clean-up procedure. Samples were extracted using C18 cartridges and eluates were then purified by gel permeation chromatography, followed by a further clean-up step on an aminopropyl cartridge. The limits of detection achieved were 0.2 ng l-1 for estriol, 17β-estradiol and 17α-ethinylestradiol, and 0.1 ng l-1 for estrone and the conjugate. The robustness of the method was demonstrated by achieving recoveries of >83% for all steroids in settled sewage and final effluent samples with relative standard deviations of 0.5 - 12%. The method was used to analyse a range of samples from a wastewater treatment works in south east England which demonstrated a >80% removal for estrone, estradiol and estriol with little impact on concentrations of ethinylestradiol or the conjugate.en
dc.format.extent248320 bytes-
dc.format.mimetypeapplication/msword-
dc.language.isoen-
dc.publisherElsevieren
dc.subjectestrogenen
dc.subjectsolid phase extractionen
dc.subjectmass spectrometryen
dc.subjectliquid chromatographyen
dc.subjectwastewateren
dc.titleDetermination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometryen
dc.typePreprinten
dc.identifier.doihttp://dx.doi.org/10.1016/j.chroma.2007.09.074-
Appears in Collections:Environment
Institute for the Environment

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