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Title: | Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma |
Authors: | Simpson, AJ Romer, LM Kippelen, P |
Keywords: | airway hyper-responsiveness;eucapnic voluntary hyperpnea;exercise-induced bronchoconstriction;exercise-induced asthma;whole-body dehydration |
Issue Date: | 1-May-2017 |
Publisher: | American Physiological Society |
Citation: | Simpson, A.J., Romer, L.M. and Kippelen, P. (2017) 'Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma', Journal of applied physiology, 122(5), pp. 1329-1335. doi: 10.1152/japplphysiol.01114.2016. |
Abstract: | Background: Local airway water loss is the main physiological trigger for exercise induced bronchoconstriction (EIB). Aim: To investigate the effects of whole-body water loss on airway responsiveness and pulmonary function in athletes with mild asthma and/or EIB. Methods: Ten recreational athletes with a doctor diagnosis of mild asthma and/or EIB completed a randomized, cross-over study. Pulmonary function tests (spirometry, whole body plethysmography and diffusing capacity for carbon monoxide [DLCO]) were conducted before and after three conditions: i) 2 h exercise in the heat with no fluid intake (dehydration); ii) 2 h exercise with ad libitum fluid intake (control); and iii) time-matched rest period (rest). Airway responsiveness was assessed 2 h post-exercise/rest via eucapnic voluntary hyperpnea (EVH) to dry air. Results: Exercise in the heat with no fluid intake induced a state of mild dehydration, with a mean body mass loss of 2.3±0.8% (SD). After EVH, airway narrowing was not different between conditions: median (interquartile range) maximum fall in forced expiratory volume in 1 sec was 13 (7–15)%, 11 (9–24)% and 12 (7–20)% in the dehydration, control and rest conditions, respectively. Dehydration caused a significant reduction in forced vital capacity (300±190 ml, P=0.001) and concomitant increases in residual volume (260±180 ml, P=0.001) and functional residual capacity (260±250 ml, P=0.011), with no change in DLCO. Conclusion: Mild exercise induced dehydration does not exaggerate airway responsiveness to dry air in athletes with mild asthma/EIB, but may affect small airway function. |
URI: | https://bura.brunel.ac.uk/handle/2438/14208 |
DOI: | https://doi.org/10.1152/japplphysiol.01114.2016 1522-1601 |
ISSN: | 8750-7587 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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