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DC Field | Value | Language |
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dc.contributor.author | Williams, DM | - |
dc.contributor.author | Palaniswamy, S | - |
dc.contributor.author | Sebert, S | - |
dc.contributor.author | Buxton, JL | - |
dc.contributor.author | Blakemore, AIF | - |
dc.contributor.author | Hyppoenen, E | - |
dc.contributor.author | Jarvelin, M-R | - |
dc.date.accessioned | 2017-06-07T15:14:44Z | - |
dc.date.available | 2016-02-01 | - |
dc.date.available | 2017-06-07T15:14:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | American Journal of Epidemiology, 183(3): pp. 191 - 198, (2016) | en_US |
dc.identifier.issn | 0002-9262 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/14695 | - |
dc.description.abstract | Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)2) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = −0.4%, 95% confidence interval: −0.6, −0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = −0.3%, 95% confidence interval −0.6, −0.1). These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at least by young adulthood. Inflammation may partly mediate associations of adiposity with LTL. | en_US |
dc.description.sponsorship | This work was supported financially by the following institutions: the Academy of Finland (grants 104781, 120315, 129269, 1114194, 24300796, and 12926); University Hospital Oulu and Biocenter Oulu, University of Oulu (grant 75617); the European Commission (grant QLG1-CT-2000- 01643); the National Heart, Lung, and Blood Institute, US National Institutes of Health (grant 5R01HL087679-02); the National Institute of Mental Health, US National Institutes of Health (grant 5R01MH63706:02); the Medical Research Council (grants G0500539, G0600705, G0601653, and K014536); the Wellcome Trust (grant GR069224); and Diabetes UK (grant 08/0003775). J.L.B. was supported by a Wellcome Trust Fellowship grant (WT088431MA). D.M.W., S.S., and M.-R.J. were supported by the European Union’s Horizon 2020 research and innovation program under grant agreement DynaHEALTH (633595). | en_US |
dc.format.extent | 191 - 198 (8) | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.subject | Biological aging | en_US |
dc.subject | Northern Finland birth cohorts | en_US |
dc.subject | Telomere length | en_US |
dc.subject | Vitamin D | en_US |
dc.title | 25-Hydroxyvitamin D concentration and Leukocyte telomere length in young adults: Findings from the Northern Finland birth cohort 1966 | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1093/aje/kwv203 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF EPIDEMIOLOGY | - |
pubs.issue | 3 | - |
pubs.notes | Estimated date added for REF requirements. | - |
pubs.publication-status | Published | - |
pubs.volume | 183 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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