Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/14934
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSala, A-
dc.date.accessioned2017-07-18T14:04:24Z-
dc.date.available2017-07-18T14:04:24Z-
dc.date.issued2017-
dc.identifier.citationOncotarget, 8 (36): 60368 - 60377 (2017)en_US
dc.identifier.issn1949-2553-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/14934-
dc.description.abstractThe endosialin/CD248/TEM1 receptor is expressed on the cell surface of tumorassociated stroma cells as well as in sarcoma and neuroblastoma cells. This receptor is emerging as an attractive molecule in diagnostics and therapeutics because of its expression across the stroma of many human tumors, the low to absent expression in normal tissues and accessibility from the vascular circulation. In this study, we present evidence of the preclinical efficacy of a novel Antibody-Drug Conjugate (ENDOS/ADC). It consists of a humanized endosialin monoclonal antibody, named hMP-E-8.3, conjugated to a potent duocarmycin derivative. In endosialin expressing cancer cell lines, this ENDOS/ADC showed a powerful, specific and target-dependent killing activity. High expression levels of endosialin in cells correlated with efficient internalization and cytotoxic effects in vitro. Efficacy studies demonstrated that ENDOS/ADC treatment led to a long-lasting tumor growth inhibition of a cell linebased model of human osteosarcoma. Taken together, our results demonstrate that endosialin is an attractive target in sarcoma and suggest that ENDOS/ADC has the potential to be developed into a bio-therapeutic agent for these malignancies.en_US
dc.language.isoenen_US
dc.subjecttarget therapyen_US
dc.subjectduocarmycinen_US
dc.subjectsarcomaen_US
dc.subjectADCen_US
dc.subjectendosialinen_US
dc.titleGeneration of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcomaen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.18632/oncotarget.19499-
dc.relation.isPartOfOncotarget-
pubs.publication-statusPublished-
Appears in Collections:Dept of Health Sciences Research Papers

Files in This Item:
File Description SizeFormat 
Fulltext.pdf4.25 MBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.