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DC Field | Value | Language |
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dc.contributor.author | Dong, Y | - |
dc.contributor.author | Lin, H | - |
dc.contributor.author | Abolghasemi, V | - |
dc.contributor.author | Gan, L | - |
dc.contributor.author | Zeitler, JA | - |
dc.contributor.author | Shen, Y-C | - |
dc.date.accessioned | 2018-12-10T12:16:16Z | - |
dc.date.available | 2017-02 | - |
dc.date.available | 2018-12-10T12:16:16Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Pharmaceutical Sciences, 2017, 106 (2), pp. 546 - 553 | en_US |
dc.identifier.issn | 0022-3549 | - |
dc.identifier.issn | http://dx.doi.org/10.1016/j.xphs.2016.09.021 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/17201 | - |
dc.description.abstract | Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating uniformity without compromising on the achievable axial resolution and imaging depth, we comprehensively examine an algebraic reconstruction technique with OCT to significantly reduce the data required. Specifically, a set of coated pharmaceutical tablets with film coating thickness in the range of 60-100 μm is investigated. Results obtained from performing the reconstruction reveal that only 30% of the acquired data are actually required leading to a faster convergence time and a generally good agreement with benchmark data against the intra-tablet coating uniformity measured with terahertz pulsed imaging technology. | en_US |
dc.format.extent | 546 - 553 | - |
dc.language.iso | en | en_US |
dc.subject | coating | en_US |
dc.subject | optical coherence tomography | en_US |
dc.subject | imaging method | en_US |
dc.subject | process analytical technology | en_US |
dc.subject | tablet | en_US |
dc.title | Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/j.xphs.2016.09.021 | - |
dc.relation.isPartOf | Journal of Pharmaceutical Sciences | - |
pubs.issue | 2 | - |
pubs.notes | publisher: Elsevier articletitle: Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography journaltitle: Journal of Pharmaceutical Sciences articlelink: http://dx.doi.org/10.1016/j.xphs.2016.09.021 content_type: article copyright: © 2017 The Authors. Published by Elsevier Inc. on behalf of the American Pharmacists Association?® . | - |
pubs.publication-status | Published | - |
pubs.volume | 106 | - |
Appears in Collections: | Dept of Electronic and Electrical Engineering Research Papers |
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Fulltext.pdf | 2.86 MB | Adobe PDF | View/Open |
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