Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/20816
Title: Weight Loss after Bariatric Surgery Significantly Improves Carotid and Cardiac Function in Apparently Healthy People with Morbid Obesity
Authors: Giudici, A
Palombo, C
Kozakova, M
Carmela M
Losso, L
Nannipieri, M
Berta, R
Hughes, AD
Cruickshank, JK
Khir, AW
Keywords: bariatric surgery;obesity;carotid artery;LV function;carotid local PWV
Issue Date: 3-Jun-2020
Publisher: Springer Verlag
Citation: Giudici, A., Palombo, C., Kozakova, M. Carmela M., Losso, L., Nannipieri, M., Berta, R., Hughes, A.D., Cruickshank, J.K. & Khir, A.W. (2020) 'Weight Loss After Bariatric Surgery Significantly Improves Carotid and Cardiac Function in Apparently Healthy People with Morbid Obesity', Obesity Surgery 30, 3776–3783. doi: 10.1007/s11695-020-04686-y.
Abstract: © The Author(s) 2020. Purpose Obesity clearly increases cardiovascular risk, often inducing high blood pressure (BP), impaired left ventricular (LV) function, and increased arterial stiffness. Intensive weight loss and bariatric surgery induce improvement in hypertension and diabetes for morbid obesity. Carotid artery haemodynamics is a powerful prognostic indicator for stroke and cognitive decline independent of BP. The aim of this study was to evaluate the impact of a 3-stage bariatric strategy of diet, bariatric surgery, and consequent weight loss on carotid haemodynamics and cardiac diastolic function. Material and Methods This prospective study included 26 patients (45 ± 10 years, 4 men) with severe obesity undergoing bariatric surgery without comorbidities (hypertension, diabetes, etc.). Anthropometry, BP, Doppler echocardiography, and common carotid haemodynamics by ultrasound were measured at three times: (1) baseline, (2) after 1-month diet (post-diet), and (3) 8 months after surgery (post-surgery). The lnDU-loop method was used to estimate local carotid pulse wave velocity (ncPWV). Results Baseline BMI was 47.9 ± 7.1 kg/m2 and reduced by 5% and 30% post-diet and post-surgery, respectively. BP decreased only post-diet, without pulse pressure change. However, ncPWV, 6.27 ± 1.35 m/s at baseline, was significantly reduced by 10% and 23% post-diet and post-surgery, respectively, also adjusted for BP changes. The E/A ratio rose from 0.95 ± 0.20 to 1.27 ± 0.31 (p < 0.005), without change in LV geometry or mass, while heart rate and cardiac output fell substantially.
URI: https://bura.brunel.ac.uk/handle/2438/20816
DOI: https://doi.org/10.1007/s11695-020-04686-y
ISSN: 0960-8923
Appears in Collections:Dept of Mechanical and Aerospace Engineering Research Papers

Files in This Item:
File Description SizeFormat 
FullText.pdf549.23 kBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.