Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/22536
Title: | The Impact of Thrombo‐inflammation on the Cerebral Microcirculation |
Authors: | Ansari, J Gavins, FNE |
Keywords: | inflammation;neutrophils;stroke;thrombosis |
Issue Date: | 26-Feb-2021 |
Publisher: | Wiley |
Citation: | Ansari, J. and Gavins, F.N.E. (2021) 'The Impact of Thrombo‐inflammation on the Cerebral Microcirculation', Microcirculation, 28 (3), e12689, pp. 1-11. doi: 10.1111/micc.12689. |
Abstract: | Copyright © 2021 The Authors. The intertwined processes of thrombosis and inflammation (termed “thrombo-inflammation”) are significant drivers of cerebrovascular diseases, and as such, they represent prime targets for drug discovery programs focusing on treatment and management of cerebrovascular diseases. Most cerebrovascular events result from chronic systemic microcirculatory dysfunction due to underlying conditions, for example, hypertension, diabetes mellitus, coronary artery disease, dyslipidemia, and sickle cell disease. Immune cells especially neutrophils play a critical role in the onset and maintenance of neuroinflammatory responses in the microcirculation. Neutrophils have the ability to drive both inflammatory and anti-inflammatory/pro-resolution effects depending on the underlying vascular state (physiological vs. pathological). In this article, we highlight the pathophysiological role of neutrophils in stroke and discuss ongoing pharmacotherapeutic strategies that are focused on identifying potential therapeutic targets for enhancing neuroprotection, mitigating inflammatory pathways, and enabling resolution. |
URI: | https://bura.brunel.ac.uk/handle/2438/22536 |
DOI: | https://doi.org/10.1111/micc.12689 |
ISSN: | 1073-9688 |
Other Identifiers: | e12689 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 1.01 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License