Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/23038
Title: | Alcohol consumption in the general population is associated with structural changes in multiple organ systems |
Authors: | Evangelou, E Suzuki, H Bai, W Pazoki, R Gao, H Matthews, PM Elliott, P |
Issue Date: | 1-Jun-2021 |
Publisher: | eLife Sciences Publications |
Citation: | Evangelou, E., Suzuki, H., Bai, W., Pazoki, R., Gao, H., Matthews, P.M. and Elliott, P. (2021) 'Alcohol consumption in the general population is associated with structural changes in multiple organ systems', eLife 10, e65325, pp. 1-15. doi: 10.7554/eLife.65325. |
Abstract: | Copyright © 2021 Evangelou et al. Background: Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample. Methods: We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta, and liver of UK Biobank participants who reported drinking alcohol. Results: We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7 ☓ 103 ± 0.76 ☓ 103 per doubling of alcohol consumption, p=3.0 ☓ 1014 ). Alcohol consumption was also associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption. Conclusions: Our results imply that there is not a ‘safe threshold’ below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited. |
URI: | https://bura.brunel.ac.uk/handle/2438/23038 |
DOI: | https://doi.org/10.7554/eLife.65325 |
Other Identifiers: | e65325 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 1.47 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License