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http://bura.brunel.ac.uk/handle/2438/23849
Title: | Thromboinflammation in coronavirus disease 2019: The clot thickens |
Authors: | Iffah, R Gavins, FNE |
Keywords: | inflammation;neutrophils;platelets;resolution pharmacology;thromboinflammation;thrombosis |
Issue Date: | 14-Jun-2021 |
Publisher: | John Wiley & Sons Ltd on behalf of British Pharmacological Society |
Citation: | Iffah, R. and Gavins, F.N.E. (2022) 'Thromboinflammation in coronavirus disease 2019: The clot thickens', British Journal of Pharmacology, 179 (10), pp. 2100 - 2107. doi: 10.1111/bph.15594. |
Abstract: | Copyright © 2021 The Authors. Since the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a disease that has become one of the world's greatest global health challenges, the role of the immune system has been at the forefront of scientific studies. The pathophysiology of coronavirus disease 2019 (COVID-19) is complex, which is evident in those at higher risk for poor outcome. Multiple systems contribute to thrombosis and inflammation seen in COVID-19 patients, including neutrophil and platelet activation, and endothelial dysfunction. Understanding how the immune system functions in different patient cohorts (particularly given recent emerging events with the Oxford/AstraZeneca vaccine) is vital to understanding the pathophysiology of this devastating disease and for the subsequent development of novel therapeutic targets and to facilitate possible drug repurposing strategies that could benefit society on a global scale. |
Description: | Data availability statement: No data have been shared. Linked articles: This article is part of a themed issue on The second wave: are we any closer to efficacious pharmacotherapy for COVID 19? (BJP 75th Anniversary). To view the other articles in this section visit https://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc |
URI: | https://bura.brunel.ac.uk/handle/2438/23849 |
DOI: | https://doi.org/10.1111/bph.15594 |
ISSN: | 0007-1188 |
Other Identifiers: | ORCID iD: Felicity N. E. Gavins https://orcid.org/0000-0001-7008-5423 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2021 The Authors. Published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | 3.2 MB | Adobe PDF | View/Open |
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