A Biomicrofluidic Screening Platform for Dysfunctional Endothelium-Targeted Nanoparticles and Therapeutics

Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/23904

Title:	A Biomicrofluidic Screening Platform for Dysfunctional Endothelium-Targeted Nanoparticles and Therapeutics
Authors:	Bazban-Shotorbani, S Gavins, F Kant, K Dufva, M Kamaly, N
Issue Date:	5-Jan-2022
Publisher:	Wiley-VCH GmbH
Citation:	Bazban-Shotorbani, S., Gavins, F., Kant, K., Dufva, M. and Kamaly, N. (2022) 'A Biomicrofluidic Screening Platform for Dysfunctional Endothelium-Targeted Nanoparticles and Therapeutics', Advanced NanoBiomed Research, 2, 2270011, pp. 1-1 [cover picture]. doi: 10.1002/anbr.202270011.
Abstract:	Copyright © 2022 The Author(s) and Wiley-VCH GmbH. Biomicrofluidic Models Biomicrofluidic models allow nanoparticle-cellular interactions to be studied under physiological flow conditions. Investigating nanoparticle biophysicochemical properties in models that resemble disease can provide valuable information about the nano-bio interface. By screening nanoparticles dynamically against a developed dysfunctional-endothelium-on chip model, Nazila Kamaly and co-workers show in article number 2100092 that nanoparticle size is a dominant factor beyond targeting ligands. Furthermore, tight junction disruption can be restored by the inflammation resolving mediator Annexin A1.
URI:	https://bura.brunel.ac.uk/handle/2438/23904
DOI:	https://doi.org/10.1002/anbr.202270011
Other Identifiers:	202270011
Appears in Collections:	Dept of Life Sciences Research Papers

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