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http://bura.brunel.ac.uk/handle/2438/24150| Title: | In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia |
| Authors: | Morse, SV Boltersdorf, T Chan, TG Gavins, FNE Choi, JJ Long, NJ |
| Issue Date: | 23-Sep-2020 |
| Publisher: | Royal Society of Chemistry (RSC) |
| Citation: | Morse, S.V., Boltersdorf, T., Chan, T.G., Gavins, F.N.E., Choi, J.J. and Long, N.J. (2020) 'In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia', RSC Chemical Biology, 1 (5), pp. 385 - 389. doi: 10.1039/d0cb00140f. |
| Abstract: | To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders. |
| URI: | https://bura.brunel.ac.uk/handle/2438/24150 |
| DOI: | https://doi.org/10.1039/d0cb00140f |
| Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | 4.37 MB | Adobe PDF | View/Open |
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