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http://bura.brunel.ac.uk/handle/2438/25374
Title: | Signalling dynamics, cell decisions, and homeostatic control in health and disease |
Authors: | Valls, PO Esposito, A |
Issue Date: | 1-Mar-2022 |
Publisher: | Elsevier |
Citation: | Valls, P.O. and Esposito, A. (2022) 'Signalling dynamics, cell decisions, and homeostatic control in health and disease', Current Opinion in Cell Biology, 75, 102066, pp. 1 - 9. doi: 10.1016/j.ceb.2022.01.011. |
Abstract: | Copyright © 2022 The Authors.. Cell signalling engenders cells with the capability to receive and process information from the intracellular and extracellular environments, trigger and execute biological responses, and communicate with each other. Ultimately, cell signalling is responsible for maintaining homeostasis at the cellular, tissue and systemic level. For this reason, cell signalling is a topic of intense research efforts aimed to elucidate how cells coordinate transitions between states in developing and adult organisms in physiological and pathological conditions. Here, we review current knowledge of how cell signalling operates at multiple spatial and temporal scales, focusing on how single-cell analytical techniques reveal mechanisms underpinning cell-to-cell variability, signalling plasticity, and collective cellular responses. |
URI: | https://bura.brunel.ac.uk/handle/2438/25374 |
DOI: | https://doi.org/10.1016/j.ceb.2022.01.011 |
ISSN: | 0955-0674 |
Other Identifiers: | 102066 ORCiD ID: Alessandro Esposito - https://orcid.org/0000-0002-5051-091X |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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FullText.pdf | 1.54 MB | Adobe PDF | View/Open |
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