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http://bura.brunel.ac.uk/handle/2438/25718| Title: | Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades |
| Authors: | Russell, LL Greaves, CV Convery, RS Bocchetta, M Warren, JD Kaski, D Rohrer, JD |
| Issue Date: | 31-Dec-2021 |
| Publisher: | Wiley Periodicals, LLC on behalf of Alzheimer's Association |
| Citation: | Russell, L.L. et al. (2021) 'Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades', Alzheimer's and Dementia: Translational Research and Clinical Interventions, 7 (1), e12218, pp. 1 - 14. doi: 10.1002/trc2.12218 |
| Abstract: | Copyright © 2021 The Authors. Introduction: Oculomotor function has not been systematically studied in frontotemporal dementia (FTD) and yet may offer a simple target to monitor disease activity. Methods: We assessed fixation stability, smooth pursuit, pro-saccades, and anti-saccades using the Eyelink 1000-plus eye-tracker in 19 individuals with behavioral variant FTD (bvFTD) and 22 controls. Neuroanatomical correlates were assessed using a region of interest magnetic resonance imaging (MRI) analysis. Results: Measures of fixation stability were impaired in the bvFTD group compared with controls. However, performance did not differ from controls in the pro-saccade tasks except in the vertical overlap condition. The bvFTD group performed worse in the anti-saccade task, which correlated strongly with executive function. Neural correlates included the orbitofrontal and ventromedial prefrontal cortices and striatum for fixation stability, and the dorsolateral prefrontal and parietal cortices and striatum for anti-saccades. Discussion: Overall, oculomotor function is abnormal in bvFTD, with performance likely related to impairment of inhibitory control and executive dysfunction. |
| URI: | https://bura.brunel.ac.uk/handle/2438/25718 |
| DOI: | https://doi.org/10.1002/trc2.12218 |
| Other Identifiers: | ORCID iD: Martina Bocchetta https://orcid.org/0000-0003-1814-5024 e12218 |
| Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | Copyright © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | 1.96 MB | Adobe PDF | View/Open |
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