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http://bura.brunel.ac.uk/handle/2438/25719
Title: | Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia |
Authors: | Benussi, A Alberici, A Samra, K Russell, LL Greaves, CV Bocchetta, M Ducharme, S Finger, E Fumagalli, G Galimberti, D Jiskoot, LC van Minkelen, R Mitchell, S Moore, K Moreno, F Nelson, A Nicholas, J Öijerstedt, L Olives, J Le Ber, I Masellis, M Nacmias, B Rowe, JB Sanchez-Valle, R Seelaar, H Synofzik, M Rohrer, JD Borroni, B GENFI Consortium Afonso, S Almeida, MR Anderl-Straub, S Andersson, C Antonell, A Archetti, S Arighi, A Balasa, M Barandiaran, M Bargalló, N Bartha, R Bender, B Bertoux, M Bertrand, A Bessi, V Black, S Borrego-Ecija, S Bouzigues, A Bras, J Brice, A Bruffaerts, R Butler, CR Camuzat, A Cañada, M Cantoni, V Caroppo, P Cash, D Castelo-Branco, M Colliot, O Convery, R Cope, T Danek, A de Mendonça, A Deramecourt, V Di Fede, G Díez, A Duro, D Fenoglio, C Ferrari, C Ferreira, CB Fox, N Freedman, M Funkiewiez, A Gabilondo, A Gauthier, S Gazzina, S Gerhard, A Giaccone, G Gorostidi, A Graff, C Guerreiro, R Heller, C Hoegen, T Indakoetxea, B Jelic, V Karnath, HO Keren, R Kuchcinski, G Laforce, R Waldo, ML Langheinrich, T Lebouvier, T Leitão, MJ Levin, J Lladó, A Lombardi, G Lombardi, J Loosli, S Maruta, C Mead, S Meeter, L Miltenberger, G |
Keywords: | definition;frontotemporal dementia;frontotemporal lobar degeneration;mild cognitive and/or behavioral and/or motor impairment;mild cognitive impairment;preclinical;presymptomatic;prodromal |
Issue Date: | 7-Dec-2021 |
Publisher: | Wiley Periodicals LLC on behalf of Alzheimer's Association |
Citation: | Benussi, A. et al. on behalf of the GENFI Consortium (2021) 'Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia', Alzheimer's and Dementia, 18 (7), pp. 1408 - 1423. doi: 10.1002/alz.12485. |
Abstract: | Copyright © 2021 The Authors. The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages. |
URI: | https://bura.brunel.ac.uk/handle/2438/25719 |
DOI: | https://doi.org/10.1002/alz.12485 |
ISSN: | 1552-5260 |
Other Identifiers: | ORCID iD: Martina Bocchetta https://orcid.org/0000-0003-1814-5024 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | 455.21 kB | Adobe PDF | View/Open |
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