Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/28814
Title: | Heat-related changes in the velocity and kinetic energy of flowing blood influence the human heart's output during hyperthermia |
Authors: | Watanabe, K Koch Esteves, N Gibson, OR Akiyama, K González-Alonso, J |
Keywords: | passive hyperthermia;cardiac output;peripheral blood flow |
Issue Date: | 1-May-2024 |
Publisher: | Wiley on behalf of The Physiological Society |
Citation: | Watanabe, K. et al. (2024) 'Heat-related changes in the velocity and kinetic energy of flowing blood influence the human heart's output during hyperthermia', The Journal of Physiology, 602 (10), pp. 2227 - 2251. doi: 10.1113/JP285760. |
Abstract: | Passive whole-body hyperthermia increases limb blood flow and cardiac output (˙Q), but the interplay between peripheral and central thermo-haemodynamic mechanisms remains unclear. Here we tested the hypothesis that local hyperthermia-induced alterations in peripheral blood flow and blood kinetic energy modulate flow to the heart and ˙Q. Body temperatures, regional (leg, arm, head) and systemic haemodynamics, and left ventricular (LV) volumes and functions were assessed in eight healthy males during: (1) 3 h control (normothermic condition); (2) 3 h of single-leg heating; (3) 3 h of two-leg heating; and (4) 2.5 h of whole-body heating. Leg, forearm, and extracranial blood flow increased in close association with local rises in temperature while brain perfusion remained unchanged. Increases in blood velocity with small to no changes in the conduit artery diameter underpinned the augmented limb and extracranial perfusion. In all heating conditions, ˙Q increased in association with proportional elevations in systemic vascular conductance, related to enhanced blood flow, blood velocity, vascular conductance and kinetic energy in the limbs and head (all R^2 ≥ 0.803; P < 0.001), but not in the brain. LV systolic (end-systolic elastance and twist) and diastolic functional profiles (untwisting rate), pulmonary ventilation and systemic aerobic metabolism were only altered in whole-body heating. These findings substantiate the idea that local hyperthermia-induced selective alterations in peripheral blood flow modulate the magnitude of flow to the heart and ˙Q through changes in blood velocity and kinetic energy. Localised heat-activated events in the peripheral circulation therefore affect the human heart's output. |
Description: | This study was conducted at the Centre for Human Performance, Exercise and Rehabilitation, Brunel University London, between March 2017 and March 2018. Data availability statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting information is available online at: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP285760#support-information-section . |
URI: | https://bura.brunel.ac.uk/handle/2438/28814 |
DOI: | https://doi.org/10.1113/JP285760 |
ISSN: | 0022-3751 |
Other Identifiers: | ORCiD: Kazuhito Watanabe https://orcid.org/0000-0002-3778-182X ORCiD: Nuno Koch Esteves https://orcid.org/0000-0002-0580-7642 ORCiD: Oliver R. Gibson https://orcid.org/0000-0001-6777-5562 ORCiD: Koichi Akiyama https://orcid.org/0000-0001-5113-9633 ORCiD: José González-Alonso https://orcid.org/0000-0002-8205-3311 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | Copyright © 2024 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | 3.24 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License