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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/4579

Title: Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community
Authors: Bunce, D
Anstey, KJ
Cherbuin, N
Burns, R
Christensen, H
Wen, W
Sachdev, PS
Publication Date: 2010
Publisher: PLoS ONE
Citation: PLoS One 5(10): e13567, Oct 2010
Abstract: Background: The association between brain white matter lesions and cognitive impairment in old age is well established. However, little is known about this association in midlife. As this information will inform policy for early preventative healthcare initiatives, we investigated non-periventricular frontal, temporal, parietal and occipital lobe white matter hyperintensities (WMH) in relation to cognitive function in 428 (232 women) community-dwelling adults aged 44 to 48 years. Results: Frontal white matter lesions were significantly associated with greater intraindividual RT variability in women, while temporal WMH were associated with face recognition deficits in men. Parietal and occipital lobe lesions were unrelated to cognitive performance. These findings did not differ when education and a range of health variables, including vascular risk factors, were taken into account. Conclusion: Gender differences in WMH-cognition associations are discussed, and we conclude that small vessel disease is present in midlife and has functional consequences which are generally not recognized. Preventative strategies should, therefore, begin early in life.
Description: The work was supported by the Leverhulme Trust and the British Academy and was funded by NHMRC of Australia Unit Grant No. 973302, Program Grant No. 179805, NHMRC project grant No. 157125, grants from the Australian Rotary Health Research Fund and the Australian Brewers Foundation. Copyright @ 2010 Bunce et al.
Sponsorship: This article is available through the Brunel Open Access Publishing Fund.
URI: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013567
http://bura.brunel.ac.uk/handle/2438/4579
DOI: http://dx.doi.org/10.1371/journal.pone.00135
ISSN: 1932-6203
Appears in Collections:Psychology
Brunel OA Publishing Fund
Dept of Life Sciences Research Papers

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