Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/5542
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Miller, D | - |
dc.contributor.author | Wheals, BB | - |
dc.contributor.author | Beresford, NA | - |
dc.contributor.author | Sumpter, JP | - |
dc.date.accessioned | 2011-07-11T11:07:48Z | - |
dc.date.available | 2011-07-11T11:07:48Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Environmental Health Perspectives 109(2): 133 - 138, Feb 2001 | en_US |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/5542 | - |
dc.description | Copyright @ 2001 Environmental Health Perspectives | en_US |
dc.description.abstract | We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17 beta -estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17<beta>-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da. | en_US |
dc.description.sponsorship | This work was supported in part under contract with the U.K. Department of Trade and Industry as part of the Government Chemist Programme. | en_US |
dc.language | EN | - |
dc.language.iso | en | en_US |
dc.publisher | National Institute of Environmental Health Sciences (NIEHS) | en_US |
dc.subject | Estrogenic activity | en_US |
dc.subject | Phenolic additives | en_US |
dc.subject | Recombinant yeast assay | en_US |
dc.title | Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1289/ehp.01109133 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel (Active) | - |
pubs.organisational-data | /Brunel/Brunel (Active)/Institute for the Environment | - |
pubs.organisational-data | /Brunel/Brunel (Active)/Research Centres | - |
pubs.organisational-data | /Brunel/Institute for the Environment | - |
pubs.organisational-data | /Brunel/Research Centres | - |
Appears in Collections: | Publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 117.27 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.