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DC Field | Value | Language |
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dc.contributor.author | Sainsbury, S | - |
dc.contributor.author | Ren, J | - |
dc.contributor.author | Saunders, NJ | - |
dc.contributor.author | Stuart, DI | - |
dc.contributor.author | Owens, RJ | - |
dc.date.accessioned | 2012-09-17T09:32:45Z | - |
dc.date.available | 2012-09-17T09:32:45Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Acta Crystallographica Section F, 68(7): 730 - 737, Jul 2012 | en_US |
dc.identifier.issn | 1744-3091 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1107/S1744309112010603/abstract | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/6672 | - |
dc.description | Copyright @ 2012 International Union of Crystallography | en_US |
dc.description.abstract | The crystal structure of the regulatory domain of NMB2055, a putative MetR regulator from Neisseria meningitidis, is reported at 2.5 Å resolution. The structure revealed that there is a disulfide bond inside the predicted effector-binding pocket of the regulatory domain. Mutation of the cysteines (Cys103 and Cys106) that form the disulfide bond to serines resulted in significant changes to the structure of the effector pocket. Taken together with the high degree of conservation of these cysteine residues within MetR-related transcription factors, it is suggested that the Cys103 and Cys106 residues play an important role in the function of MetR regulators. | en_US |
dc.description.sponsorship | This study is funded by the Medical Research Council, with additional finance from the Biotechnology and Biological Science Research Council. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Union of Crystallography | en_US |
dc.subject | MetR | en_US |
dc.subject | Neisseria meningitidis | en_US |
dc.subject | LysR-type regulator | en_US |
dc.title | Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1107/S1744309112010603 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care/Biological Sciences | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Biological Sciences Publications Dept of Life Sciences Research Papers |
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Fulltext.pdf | 1.93 MB | Adobe PDF | View/Open |
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