http://bura.brunel.ac.uk/handle/2438/8612 2026-07-03T21:06:19Z 2026-07-03T21:06:19Z Girginov, V http://bura.brunel.ac.uk/handle/2438/33553 2026-07-02T11:54:13Z 2026-06-18T00:00:00Z

Title: Sport Management and Sustainability: An Impossible Theorem? Authors: Girginov, V Abstract: This conceptual paper extends the debate about sustainability and sport management by transcending the dominant natural environmental perspective and offering a systems approach. Addresses the question, ‘Is sustainability in sport management possible?’ The nature of sustainability in sport management is discussed in the context of the tensions between the current growth model of sport, sport management research and teaching, and the sustainability imperative. Sustainability in sport management is concerned with a composite problem, and its goal is to understand and shape the interactions between complex adaptive natural systems and sport organizations as soft socio-economic entities at individual, organizational, and societal levels. A key feature that distinguishes sustainability in sport management from its current mainstream understanding and practices based on the ideology of growth ought to be its explicit prioritization of all types of sport participants as citizens, as opposed to treating them as consumers. At present, sustainability in sport management remains an impossibility.

2026-06-18T00:00:00Z Ofuso-Dankwa, J Sisu, C Anderson, R http://bura.brunel.ac.uk/handle/2438/33496 2026-06-24T02:00:56Z 2026-01-01T00:00:00Z

Title: Somatic Mutation Profiles in Aged Military Nuclear Test Veterans: A comparative whole-genome sequence study. Authors: Ofuso-Dankwa, J; Sisu, C; Anderson, R Abstract: ... Description: ...

2026-01-01T00:00:00Z Hashemloo, MA Killelea, T Mamić, T Ireland, TH Lou-Hing, A Kemm, F Dimude, JU Žagar, M Ivančić-Baće, I Rudolph, CJ Bolt, EL http://bura.brunel.ac.uk/handle/2438/33468 2026-06-20T02:01:18Z 2026-06-08T00:00:00Z

Title: Visualizing the interplay of Cas1–Cas2 with DNA replication-repair that creates CRISPR–Cas immunity Authors: Hashemloo, MA; Killelea, T; Mamić, T; Ireland, TH; Lou-Hing, A; Kemm, F; Dimude, JU; Žagar, M; Ivančić-Baće, I; Rudolph, CJ; Bolt, EL Abstract: Prokaryotic CRISPR–Cas systems rely on the Cas1–Cas2 protein complex to capture new DNA from mobile genetic elements (MGEs), to form immunological memory that defends against the MGEs. However, the mechanisms by which Cas1–Cas2 locates suitable DNA substrates inside cells remain unclear, limiting our understanding of how CRISPR–Cas immunity arises de novo. We directly visualized functional, DNA-bound Cas1–Cas2 complexes in bacteria, revealing the processes that license Cas1–Cas2 to capture DNA. Visible DNA-bound Cas1–Cas2 complexes formed only when replisomes are actively advancing, accumulating at post-replicative DNA gaps behind replication forks—structures arising during normal genome duplication, which are normally repaired by homologous recombination. Replication stress, which increases replicative DNA gap frequency, enhanced visible Cas1–Cas2 DNA binding. DNA capture by Cas1–Cas2 was strongly stimulated in cells lacking the RecFOR complex, which normally directs DNA gaps to repair. The RecBCD recombination initiator complex was essential for DNA capture by Cas1–Cas2 in these cells. The findings support a model in which naïve CRISPR–Cas adaptation is licensed by abundant replication-dependent DNA repair intermediates, prior to their repair by recombination. This identifies the mechanism co-ordinating Cas1–Cas2 with essential DNA replication and repair processes that all cells need, including when they are hijacked to replicate parasitic MGEs. Description: Data availability: The data referred to in this work have been deposited in Figshare (https://figshare.com) with digital object identifier: 10.6084/m9.figshare.30813251; Supplementary data are available online at: https://academic.oup.com/nar/article/54/11/gkag564/8703704?login=true#565026736 .; M. Amin Hashemloo, Tom Killelea and Tomislav Mamić should be regarded as joint first authors.

2026-06-08T00:00:00Z Szameitat, DP Wildgruber D Szameitat, AJ http://bura.brunel.ac.uk/handle/2438/33460 2026-06-19T02:01:24Z 2026-06-16T00:00:00Z

Title: Effects of aging on recognition and dominance perception in laughter Authors: Szameitat, DP; Wildgruber D; Szameitat, AJ Abstract: Introduction: Aging is associated with reduced accuracy in recognizing others’ emotions, an ability that is important for maintaining social connectedness in later life. Laughter is a social signal with multiple functions, as it can facilitate social bonding but also convey negative social meanings, for example when directed at someone. In previous research we have shown that younger adults are able to classify spontaneously emitted joyful, schadenfreude, and tickling laughter above chance level, and that these laughter sounds differ according to the perceived dominance. Given evidence that affect recognition generally declines with age, the present study examined whether comparable age effects emerge in the perception of laughter. Methods: 64 younger adults (mean 25 years, 18–33 years) and 30 older adults (mean age 60 years, 50–77 years) evaluated 117 spontaneously emitted laughter sounds according to the laughter type, i.e., joyful, Schadenfreude, and tickling laughter and according to the perceived sender’s dominance. Results: Results showed that both age groups classified laughter above chance level. Younger adults showed higher classification rates than older adults for all laughter types, with the largest age effect for Schadenfreude laughter. The dominance ratings showed an age effect only for Schadenfreude, where older adults rated Schadenfreude laughter less dominant than younger adults. Discussion: Pronounced differences in Schadenfreude perception might be ascribed to difficulties of older adults in perceiving non-literal messages or to cultural differences between age groups. Description: Data availability statement: The original contributions presented in the study are publicly available. This data can be found here: Figshare, https://doi.org/10.17633/rd.brunel.32521458.

2026-06-16T00:00:00Z