http://bura.brunel.ac.uk/handle/2438/13040 Wed, 03 Jun 2026 09:05:15 GMT 2026-06-03T09:05:15Z http://bura.brunel.ac.uk/handle/2438/33321 Title: Defining a diaphragm-focussed and patient-acceptable Inspiratory Muscle Training (IMT) load in difficult to wean, mechanically ventilated patients. A protocol for a prospective, mixed methods study Authors: Jenkins, TO; Polkey, MI; McWilliams, D; Kilbride, C; MacBean, V Abstract: ... Description: ... Thu, 01 Jan 2026 00:00:00 GMT http://bura.brunel.ac.uk/handle/2438/33321 2026-01-01T00:00:00Z http://bura.brunel.ac.uk/handle/2438/33157 Title: Navigating Transition to Adulthood: Perspectives from Young People with Cerebral Palsy, Parents, and Health Professionals Authors: Norris, M; Fortune, J; Ryan, J; Walsh, A; Kroll, T; Lavelle, G; Hensey, O Abstract: ... Description: ... Thu, 01 Jan 2026 00:00:00 GMT http://bura.brunel.ac.uk/handle/2438/33157 2026-01-01T00:00:00Z http://bura.brunel.ac.uk/handle/2438/32804 Title: Safeguarding from power: trauma, violence and the case of Israel Authors: Hakak, Y Abstract: Since October 2023, numerous international human rights organisations, special observers, journalists and scholars have documented the genocidal violence inflicted on Palestinians by the Israeli army and the settlers – violence that is often live-streamed. Their calls to safeguard the Palestinian people in Gaza and the West Bank from Israeli violence have largely fallen on deaf ears. I will therefore try to provide additional evidence and justification for international intervention by shifting the focus to the Israeli side, which is holding and abusing unrestrained powers... Description: Editorial Commentary. Thu, 15 Jan 2026 00:00:00 GMT http://bura.brunel.ac.uk/handle/2438/32804 2026-01-15T00:00:00Z http://bura.brunel.ac.uk/handle/2438/32087 Title: Amputation for complex regional pain syndrome: a systematic review Authors: Gilanyi, Y; Ferraro, MC; Goebel, A; O'Connell, NE; Jones, MD; Sharma, S; Bean, D; Gustin, SM; McAuley, JH Abstract: Complex regional pain syndrome (CRPS) is a disabling pain condition, usually confined to a single limb. Amputation of the affected limb is sometimes performed to improve pain and function for treatment-resistant CRPS. This systematic review evaluated the benefits and harms of amputation for CRPS. Primary studies of adults with CRPS that investigated the effects of amputation of a CRPS affected limb were included. Primary outcomes were pain intensity and adverse events. The following databases were searched from inception to 23 September 2024: PubMed, EMBASE, Scopus, CENTRAL, CINAHL, and PsycINFO for published literature, and BASE, Web of Science, OpenMD and MedNar for grey literature. Study methodological quality was assessed using Joanna Briggs Institute critical appraisal tools. Data were synthesised using systematic review without meta-analysis guidance. The review included 66 studies, comprising one comparative study, 23 case series and 42 case studies. Studies included 249 patients who received 263 amputations. Amputation indications included pain relief, functional improvement, infection, fracture, and prosthetic complications. The heterogeneous designs of included studies precluded quantitative estimation of treatment effects. The only included comparative study reported that CRPS patients had lower mean pain intensity scores post-amputation than non-amputated, non-matched control patients. The four studies that assessed pain intensity scores before amputation and at least 6 months post-operatively, reported reductions in average pain post-amputation. Adverse events in assessed patients included phantom pain (67%), residual limb pain (66%), and recurrence of CRPS (47%). The critically low quality of included evidence and incomplete reporting greatly reduced confidence in the results. This review found no clear evidence that amputation of a CRPS-affected limb offers greater pain relief than no amputation. High-quality, controlled prospective studies with embedded qualitative research are needed to determine the benefits and harms of amputation for CRPS, as well as the factors that drive patients to seek this permanent intervention that does not guarantee improvement. Description: Perspective: This article presents a systematic review of the benefits and harms of amputation for complex regional pain syndrome. The unclear benefits and likely harms can help inform individuals and clinicians considering amputation of the potential outcomes of this intervention. Fri, 03 Oct 2025 00:00:00 GMT http://bura.brunel.ac.uk/handle/2438/32087 2025-10-03T00:00:00Z