Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/14653
Title: | Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 |
Authors: | Ala-Mursula, L Buxton, JL Ek, E Koiranen, M Taanila, A Blakemore, AIF Jarvelin, M-R |
Keywords: | Science & Technology;Multidisciplinary Sciences;Science & Technology - Other Topics;MULTIDISCIPLINARY SCIENCES;LIFE STRESS;FOLLOW-UP;LENGTH;WOMEN;DISEASE;HEALTH;EPIDEMIOLOGY;EMPLOYMENT;BIOMARKER;CANCER |
Issue Date: | 2013 |
Publisher: | Public Library of Science |
Citation: | PLOS ONE, 8 (11): (2013) |
Abstract: | Objective: Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging. Methods: We used data from 5620 men and women belonging to the Northern Finland Birth Cohort 1966. Individually registered unemployment days in 1995–97 were compared with data on biological, behavioral and socioeconomic health predictors and existing medical conditions obtained by surveys and clinical examinations at follow-up in 1997–98. Mean LTL at follow-up was measured by multiplex quantitative real-time PCR. We calculated odds ratios and their 95% confidence intervals (CI) of belonging to the sex-stratified shortest decile of standardized relative mean LTL according to the categories of: 0, ,260, ,500 and over 500 unemployment days, representing 0, ,1, ,2 and over 2 calendar years.Results: Among men, unemployment exceeding 500 days during three years was associated with having shorter LTL at follow-up, compared to being continuously employed. The corresponding odds ratio was 2.61 (95% CI 1.16 to 5.85) in the fully adjusted model. Such an association was not found among women in this study. Conclusions: Long-term unemployment in early adulthood is associated with shorter LTL among men. Citation: |
URI: | http://bura.brunel.ac.uk/handle/2438/14653 |
DOI: | http://dx.doi.org/10.1371/journal.pone.0080094 |
ISSN: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327313100074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 UNSP e80094 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327313100074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 UNSP e80094 1932-6203 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 278.11 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.