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http://bura.brunel.ac.uk/handle/2438/3065
Title: | Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model |
Authors: | Argaman, M Gidron, Y Ariad, S |
Keywords: | Hopelessness; Cancer; Progression; Psychoneuroimmunology; IL-1β |
Issue Date: | 2005 |
Publisher: | Lawrence Erlbaum Associates |
Citation: | International Journal of Behavioral Medicine. 12(3): 16 -170 |
Abstract: | A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations of IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway. |
URI: | http://bura.brunel.ac.uk/handle/2438/3065 |
DOI: | http://dx.doi.org/10.1207/s15327558ijbm1203_5 |
Appears in Collections: | Community Health and Public Health Dept of Health Sciences Research Papers |
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803101_751310820_784771017.pdf | 269.13 kB | Adobe PDF | View/Open |
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