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Title: White matter hyperintensities and within-person variability in community-dwelling adults aged 60–64 years
Authors: Bunce, D
Anstey, KJ
Christensen, H
Dear, K
Wen, W
Sachdev, P
Keywords: White matter hyperintensities;MRI; Cognitive function; Within-person variability; Intra-individual variability
Issue Date: 2007
Publisher: Elsevier
Citation: Neuropsychologia. 45 (9) 2009-2015
Abstract: Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60–64 years. Frontal lobe WMH but not WMH from other brain regions (temporal, parietal, and occipital lobes, anterior and posterior horn, periventricular body) were associated with elevated within-person reaction time (RT) variability (trial to trial fluctuations in RT performance) but not performance on several other cognitive tasks including psychomotor speed, memory, and global cognition. The findings are consistent with the view that elevated within-person variability is related to neurobiological disturbance, and that attentional mechanisms supported by the frontal cortex play a key role in this type of variability.
ISSN: 0028-3932
Appears in Collections:Psychology
Dept of Life Sciences Research Papers

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