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|Title: ||Congenital imperforate hymen with hydrocolpos and hydronephrosis associated with severe hydramnios and increase of maternal ovarian steroidogenic enzymes|
|Authors: ||Karteris, E|
|Publication Date: ||2010|
|Citation: ||Journal of pediatric and adolescent gynecology.|
|Abstract: ||Study Objective: To study clinical features of patient presented with severe hydramnios, associated with hydronephrosis, that was antenatally diagnosed and has
been successfully treated immediately after birth. At a molecular level, we investigated the gene expression of key steroidogenic enzymes from the maternal ovary.
Design: Ultrasound scan,MRI, semi-quantitativeRT-PCR
Setting: The patient was admitted to the University Hospital,
University of Crete, Medical School, Greece, where
all clinical data has been obtained. Gene expression studies
took place at Biosciences, Brunel University, UK.
Results: Semi-quantitative RT-PCR analyses revealed
that there is upregulation of key steroidogenic genes in
the maternal ovary, including steroidogenic acute regulatory
protein, and the cytochrome P450 heme-containing
proteins CYP11A, CYP17 and CYP19. From a clinical perspective,
the prenatal ultrasound scan and MRI findings
showed a multicystic pelvic mass, bilateral hydronephrosis
and prior to delivery severe polyhydramnios.
Conclusion: This clinical case is the only one that we
have found in the current literature where congenital imperforate
hymen accompanied with hematocolpos is associated
with renal obstruction in combination with polyhydramnios
and increase in maternal steroidogenic enzymes.|
|Description: ||This is a clinical research paper|
|Appears in Collections:||Biological Sciences|
Dept of Life Sciences Research Papers
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