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Title: Meeting report: Risk assessment of tamiflu use under pandemic conditions
Authors: Singer, AC
Howard, BM
Johnson, AC
Knowles, CJ
Jackman, S
Accinelli, C
Caracciolo, AB
Bernard, I
Bird, S
Boucard, T
Boxall, A
Brian, JV
Cartmell, E
Chubb, C
Churchley, J
Costigan, S
Crane, M
Dempsey, MJ
Dorrington, B
Ellor, B
Fick, J
Holmes, J
Hutchinson, T
Karcher, F
Kelleher, SL
Marsden, P
Noone, G
Nunn, MA
Oxford, J
Rachwal, T
Roberts, N
Roberts, M
Sacca, ML
Sanders, M
Straub, JO
Terry, A
Thomas, D
Toovey, S
Townsend, R
Vouivoulis, N
Watts, C
Keywords: Antiviral;Drug;Ecotoxicology;Influenza;Pandemic;Pharmaceutical;Pollution;Sewage treatment plant;Tamiflu
Issue Date: 2008
Publisher: National Institute of Environmental Health Sciences (NIEHS)
Citation: Environmental Health Perspectives, 116(11): 1563-1567, Nov 2008
Abstract: On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of Tamiflu during an influenza pandemic. Based on the identification and risk-ranking of knowledge gaps, the consensus was that oseltamivir ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to pose an ecotoxicologic hazard to freshwater organisms. OC in river water might hasten the generation of OC-resistance in wildfowl, but this possibility seems less likely than the potential disruption that could be posed by OC and other pharmaceuticals to the operation of sewage treatment plants. The work-group members agreed on the following research priorities: a) available data on the ecotoxicology of OE-P and OC should be published; b) risk should be assessed for OC-contaminated river water generating OC-resistant viruses in wildfowl; c) sewage treatment plant functioning due to microbial inhibition by neuraminidase inhibitors and other antimicrobials used during a pandemic should be investigated; and d) realistic worst-case exposure scenarios should be developed. Additional modeling would be useful to identify localized areas within river catchments that might be prone to high pharmaceutical concentrations in sewage treatment plant effluent. Ongoing seasonal use of Tamiflu in Japan offers opportunities for researchers to assess how much OC enters and persists in the aquatic environment.
Description: EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or figures copyrighted by other commercial organizations and individuals that may not be used without obtaining prior approval from both the EHP editors and the holder of the copyright. Use of any materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives") and a reference provided for the article from which the material was reproduced.
ISSN: 0091-6765
Appears in Collections:Institute for the Environment

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