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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/4981

Title: Male reproductive health and environmental xenoestrogens
Authors: Toppari, J
Larsen, JC
Christiansen, P
Giwercman, A
Grandjean, P
Guillette, LJJ
Jégou, B
Jensen, TK
Jouannet, P
Keiding, N
Leffers, H
McLachlan, JA
Meyer, O
Müller, J
Meyts, ERD
Scheike, T
Sharpe, R
Sumpter, JP
Skakkebæk, NE
Keywords: Male reproduction
Reproductive disorders
Semen quality
Testicular neoplasms
Environment
Estrogenic chemicals
Endocrine disruptors
Exposure
Pesticides
Publication Date: 1996
Publisher: National Institute of Environmental Health Science
Citation: Environmental Health Perspectives Supplements 104(S4): 741–803, Aug 1996
Abstract: Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.
Description: EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or figures copyrighted by other commercial organizations and individuals that may not be used without obtaining prior approval from both the EHP editors and the holder of the copyright. Use of any materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives") and a reference provided for the article from which the material was reproduced.
Sponsorship: Supported by EU Contract BMH4-CT96-0314.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469672/
http://bura.brunel.ac.uk/handle/2438/4981
ISSN: 1078-0475
Appears in Collections:Institute for the Environment Research Papers

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