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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/6640

Title: Adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress
Authors: Jones, A
McMillan, MR
Jones, RW
Kowalik, GT
Steeden, JA
Deanfield, JE
Pruessner, JC
Taylor, AM
Muthurangu, V
Publication Date: 2012
Publisher: Public Library of Science
Citation: PLoS One, 7(6): e39143, Jun 2012
Abstract: Obesity and mental stress are potent risk factors for cardiovascular disease but their relationship with each other is unclear. Resilience to stress may differ according to adiposity. Early studies that addressed this are difficult to interpret due to conflicting findings and limited methods. Recent advances in assessment of cardiovascular stress responses and of fat distribution allow accurate assessment of associations between adiposity and stress responsiveness. We measured responses to the Montreal Imaging Stress Task in healthy men (N=43) and women (N=45) with a wide range of BMIs. Heart rate (HR) and blood pressure (BP) measures were used with novel magnetic resonance measures of stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR) and arterial compliance to assess cardiovascular responses. Salivary cortisol and the number and speed of answers to mathematics problems in the task were used to assess neuroendocrine and cognitive responses, respectively. Visceral and subcutaneous fat was measured using T2*-IDEAL. Greater BMI was associated with generalised blunting of cardiovascular (HR:β=−0.50 bpm.unit−1, P=0.009; SV:β=−0.33 mL.unit−1, P=0.01; CO:β=−61 mL.min−1.unit−1, P=0.002; systolic BP:β=−0.41 mmHg.unit−1, P=0.01; TPR:β=0.11 WU.unit−1, P=0.02), cognitive (correct answers: r=−0.28, P=0.01; time to answer: r=0.26, P=0.02) and endocrine responses (cortisol: r=−0.25, P=0.04) to stress. These associations were largely determined by visceral adiposity except for those related to cognitive performance, which were determined by both visceral and subcutaneous adiposity. Our findings suggest that adiposity is associated with centrally reduced stress responsiveness. Although this may mitigate some long-term health risks of stress responsiveness, reduced performance under stress may be a more immediate negative consequence.
Description: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - Copyright @ 2012 Jones et al.
Sponsorship: This work is funded by the UK National Institute of Health Research (NIHR), Siemens Medical Systems, British Heart Foundation (BHF), NIHR Senior Research Fellowship & The Fondation Leducq, BHF Intermediate Fellowship.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380036/?tool=pmcentrez
http://bura.brunel.ac.uk/handle/2438/6640
DOI: http://dx.doi.org/10.1371/journal.pone.0039143
ISSN: 1932-6203
Appears in Collections:Information Systems and Computing
School of Information Systems, Computing and Mathematics Theses

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