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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/6663

Title: CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms
Authors: Maloy, KJ
Salaun, L
Cahill, R
Dougan, G
Saunders, NJ
Powrie, F
Keywords: Regulatory T cells
Helicobacter
Immune tolerance
Mucosal immunity
IL-10
Publication Date: 2003
Publisher: Rockefeller University Press
Citation: Journal of Experimental Medicine, 197(1): 111-119, Jan 2003
Abstract: CD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell–reconstituted recombination-activating gene (RAG)−/− mice as a model to study the ability of CD4+CD25+ TR cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell–independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4+CD25+ TR cells. T cell–independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4+CD25+ TR cells. Suppression of innate immune pathology was dependent on T cell–derived interleukin 10 and also on the production of transforming growth factor β. Thus, CD4+CD25+ TR cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms.
Description: Copyright @ 2003 The Rockefeller University Press
Sponsorship: This project was supported by a Wellcome Trust Project grant (F. Powrie) and by Wellcome Trust Fellowships (F. Powrie and N.J. Saunders).
URI: http://jem.highwire.org/content/197/1/111.abstract
http://bura.brunel.ac.uk/handle/2438/6663
DOI: http://dx.doi.org/10.1084/jem.20021345
ISSN: 0022-1007
Appears in Collections:School of Health Sciences and Social Care Research Papers
Biosciences
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