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Title: CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms
Authors: Maloy, KJ
Salaun, L
Cahill, R
Dougan, G
Saunders, NJ
Powrie, F
Keywords: Regulatory T cells;Helicobacter;Immune tolerance;Mucosal immunity;IL-10
Issue Date: 2003
Publisher: Rockefeller University Press
Citation: Journal of Experimental Medicine, 197(1): 111-119, Jan 2003
Abstract: CD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell–reconstituted recombination-activating gene (RAG)−/− mice as a model to study the ability of CD4+CD25+ TR cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell–independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4+CD25+ TR cells. T cell–independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4+CD25+ TR cells. Suppression of innate immune pathology was dependent on T cell–derived interleukin 10 and also on the production of transforming growth factor β. Thus, CD4+CD25+ TR cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms.
Description: Copyright @ 2003 The Rockefeller University Press
ISSN: 0022-1007
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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