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Title: Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides
Authors: Benner, MF
Ballabio, E
van Kester, MS
Saunders, NJ
Vermeer, MH
Willemze, R
Lawrie, CH
Tensen, CP
Keywords: miR-155;miRNA microarray;Mycosis fungoides;Primary cutaneous anaplastic large cell lymphoma;Q-PCR
Issue Date: 2012
Publisher: John Wiley and Sons
Citation: Experimental Dermatology, 21(8): 632 - 634, Aug 2012
Abstract: The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoides (MF). We identified 13 differentially expressed miRNAs between C-ALCL and BID. The up-regulation of miR-155, miR-27b, miR-30c and miR-29b in C-ALCL was validated by miRNA-Q-PCR on independent study groups. Additionally, the miRNA expression profiles of C-ALCL were compared with those of tumor-stage MF. Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL. This study, the first describing the miRNA expression profile of C-ALCL, reveals differences with tumor-stage MF, suggesting a different contribution to the pathogenesis of these lymphomas.
Description: Copyright @ 2012 John Wiley & Sons
ISSN: 0906-6705
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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