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Title: Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides
Authors: Benner, MF
Ballabio, E
van Kester, MS
Saunders, NJ
Vermeer, MH
Willemze, R
Lawrie, CH
Tensen, CP
Keywords: miR-155
miRNA microarray
Mycosis fungoides
Primary cutaneous anaplastic large cell lymphoma
Publication Date: 2012
Publisher: John Wiley and Sons
Citation: Experimental Dermatology, 21(8): 632 - 634, Aug 2012
Abstract: The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoides (MF). We identified 13 differentially expressed miRNAs between C-ALCL and BID. The up-regulation of miR-155, miR-27b, miR-30c and miR-29b in C-ALCL was validated by miRNA-Q-PCR on independent study groups. Additionally, the miRNA expression profiles of C-ALCL were compared with those of tumor-stage MF. Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL. This study, the first describing the miRNA expression profile of C-ALCL, reveals differences with tumor-stage MF, suggesting a different contribution to the pathogenesis of these lymphomas.
Description: Copyright @ 2012 John Wiley & Sons
Sponsorship: This work was funded by grants from Netherlands Organization for Scientific Research (NWO) (MHV) and the Fondation ReneĀ“ Touraine (MvK), and grants from the Leukaemia and Lymphoma Research (EB) and the Julian Starmer-Smith Memorial Fund (CHL).
ISSN: 0906-6705
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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