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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/6813

Title: Multicompartmental poroelastic modelling for CSF production and circulation
Authors: Vardakis, JC
Tully, B
Byrne, J
Ventikos, Y
3rd Micro and Nano Flows Conference (MNF2011)
Keywords: Cerebrospinal fluid
Choroid plexus
Hydrocephalus
Porous media
Ventriculostomy
MRI
Publication Date: 2011
Publisher: Brunel University
Citation: 3rd Micro and Nano Flows Conference, Thessaloniki, Greece, 22-24 August 2011
Abstract: This study proposes the implementation of a Multiple-Network Poroelastic Theory (MPET) model for the purpose of investigating in detail the transport of water within the cerebral environment. The advantage of using the MPET representation is that it accounts for fluid transport between CSF, brain parenchyma and cerebral blood. They key novelty in the model discussed in the present study is the amalgamation of anatomically accurate Choroid Plexus regions, with their individual feeding arteries. This model is used to demonstrate the impact of aqueductal stenosis and atresia of the Foramina of Luschka and Magendie on the cerebral ventricles. The possible implications of treating such a condition with the aid of endoscopic third ventriculostomy are investigated and discussed.
Description: This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.
Sponsorship: This study is supported by the Research Councils UK cross council initiative led by EPSRC and contributed to by AHRC, ESRC, and MRC.
URI: http://bura.brunel.ac.uk/handle/2438/6813
ISBN: 978-1-902316-98-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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