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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/6845

Title: Wall shear stress and low density lipoprotein concentration in stented arteries
Authors: Soulis, JV
Fytanidis, DK
Seralidou, KV
Karagkiozaki, VC
Giannoglou, GD
3rd Micro and Nano Flows Conference (MNF2011)
Keywords: Wall shear stress
LDL transport
Stented artery
Publication Date: 2011
Publisher: Brunel University
Citation: 3rd Micro and Nano Flows Conference, Thessaloniki, Greece, 22-24 August 2011
Abstract: Current computational analysis results quantify Wall Shear Stress (WSS) and its impact on Low Density Lipoprotein (LDL) concentration of a fully deployed straight artery stent. Atherosclerosis shows predilection in arterial regions with hemodynamic particularities, as local disturbances of WSS in space, and locally high concentrations of lipoprotein. The WSS and subsequently the LDL distribution are important indicators of stent performance. A typical 6.0 mm diameter straight stented artery is used to elucidate the WSS and the LDL transport under steady flow conditions treating the blood as a non-Newtonian fluid. Struts are 50.0 % embedded into the arterial wall. Emphasis is placed in the LDL distribution at the upstream and downstream flow regions of each strut intersection. Reduced WSS values are observed towards outlet. At the strut intersections, high WSS values are observed possibly causing platelet activation. Prone to plaque development are flow regions located at specific strut intersections (mostly at the vicinity of the curved struts) where increased LDL concentration is observed. The maximum LDL concentration over the stented artery reaches a value of 3.8 % higher than that at the entrance. The concentration at distal to any strut region was higher than proximal to the strut.
Description: This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.
URI: http://bura.brunel.ac.uk/handle/2438/6845
ISBN: 978-1-902316-98-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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