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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/6863

Title: Blood flow in microvascular networks
Authors: Mansour, MH
Bressloff, NW
Shearman, CP
2nd Micro and Nano Flows Conference (MNF2009)
Keywords: Non-Newtonian
Microvascular
Network
Red blood cell depletion model
Quemada model
Publication Date: 2009
Publisher: Brunel University
Citation: 2nd Micro and Nano Flows Conference, Brunel University, West London, UK, 01-02 September 2009
Abstract: Simulation of blood presents a very complex haemodynamics problem especially in relation to the understanding of atherogenesis. In many simulations, blood has been treated as a single-phase homogeneous fluid, a classical approach that does not account for the presence of red blood cells (RBCs). Although this approach provides satisfactory tools to describe certain aspects of blood flow in large arteries, it fails to give an adequate representation of the flow field in the vessels of smaller diameter where the size of the RBC becomes significant relative to vessel diameter. So, this article is concerned with the study of non-Newtonian blood flow in microvascular networks with the intention of developing a new cell depletion layer model to represent the behaviour of RBCs through bifurcating networks. The model is tested in a microvascular network constructed possessing realistic bifurcation features, with controlled dimensions and angles. The RBC depletion model treats blood as two continuum layers, with a central, non-Newtonian core region of concentrated red cell suspension that is surrounded by a layer of plasma (Newtonian fluid) adjacent to the vessel wall. In the central core region, blood is described by Quemada's non-Newtonian rheological model. Geometry differences are shown to significantly affect flow rates, haematocrit distributions and the corresponding cell depletion layers.
Description: This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.
URI: http://bura.brunel.ac.uk/handle/2438/6863
ISBN: 978-1-902316-72-7
ISSN: 978-1-902316-73-4
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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