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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/6908

Title: Influence of the microvasculature on oxygen transport in human brain tissue
Authors: Su, SW
Payne, SJ
2nd Micro and Nano Flows Conference (MNF2009)
Keywords: Micro flow
Microcirculation
Dementia
Oxygen transport
Publication Date: 2009
Publisher: Brunel University
Citation: 2nd Micro and Nano Flows Conference, Brunel University, West London, UK, 01-02 September 2009
Abstract: Two numerical methods are presented for simulating a micro-stroke: a discretised model and a continuum model, both developed for simulating coupled flow and oxygen transport to the microvasculature. The discrete model treats the microvasculature and the tissue perfusion as two coupled sub-systems governed by Poiseulle flow and mass transport equation respectively. The continuum model regards the blood passage as a porous media flow and deals with mass transport in terms of a two phase flow system. In our simulations, it has been shown that the microvascular structure has a strong influence on the localized oxygen transport behaviour, contributing to more complex patterns in the tissue oxygen concentration than those found by assuming continuum behaviour.
Description: This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.
URI: http://bura.brunel.ac.uk/handle/2438/6908
ISBN: 978-1-902316-72-7
978-1-902316-73-4
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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