Brunel University Research Archive (BURA) >
University >
The Brunel Collection >

Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/6924

Title: Temperature-based tuning of magnetic particle separation by on-chip free-flow magnetophoresis
Authors: Tarn, MD
Robert, D
Peyman, SA
Iles, A
Wilhelm, C
Pamme, N
2nd Micro and Nano Flows Conference (MNF2009)
Keywords: Magnetophoresis
Magnetic particles
Separation
Temperature dependence
Viscosity
Continuous flow
Publication Date: 2009
Publisher: Brunel University
Citation: 2nd Micro and Nano Flows Conference, Brunel University, West London, UK, 01-02 September 2009
Abstract: Free-flow magnetophoresis provides a fast and efficient means of continuous flow magnetic separation for the detection of biological analytes, due to the wide variety of magnetic particle surface properties available for binding specific targets. Here, we investigate the effect of temperature changes on the deflection behaviour of magnetic particles in a microfluidic magnetophoresis separation chamber. It was found that the extent of deflection was greatly increased at higher temperatures due to decreased solution viscosity and thus reduced resistance against particle motion. This concept was used to improve the resolution of the separation of 2.8 μm and 1 μm diameter magnetic particles. Hence, controlling the temperature of the separation system provides a simple but highly effective means of enhancing magnetic separation efficiency. This concept could also be applied to the temperature-based tuning of microparticle trajectories in many others types of continuous flow processes, such as those using optical, electrical or acoustic forces.
Description: This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.
Sponsorship: This study is funded by the Engineering and Physical Sciences Research Council (EPSRC).
URI: http://bura.brunel.ac.uk/handle/2438/6924
ISBN: 978-1-902316-72-7
978-1-902316-73-4
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

Files in This Item:

File Description SizeFormat
MNF2009.pdf2.02 MBAdobe PDFView/Open

Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.

 


Library (c) Brunel University.    Powered By: DSpace
Send us your
Feedback. Last Updated: September 14, 2010.
Managed by:
Hassan Bhuiyan