Brunel University Research Archive (BURA) >
College of Engineering, Design and Physical Sciences >
Dept of Computer Science >
Dept of Computer Science Research Papers >

Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/3037

Title: An introduction to Biomodel engineering, illustrated for signal transduction pathways
Authors: Gilbert, D
Breitling, R
Heiner, M
Donaldson, R
Publication Date: 2009
Publisher: WMC
Citation: Proceedings of the 9th International Workshop, WMC 2008, Edinburgh, UK, 28-31 July 2008
Abstract: BioModel Engineering is the science of designing, constructing and analyzing computational models of biological systems. It is inspired by concepts from software engineering and computing science. This paper illustrates a major theme in BioModel Engineering, namely that identifying a quantitative model of a dynamic system means building the structure, finding an initial state, and parameter fitting. In our approach, the structure is obtained by piecewise construction of models from modular parts, the initial state is obtained by analysis of the structure and parameter fitting comprises determining the rate parameters of the kinetic equations. We illustrate this with an example in the area of intracellular signalling pathways.
URI: http://bura.brunel.ac.uk/handle/2438/3037
ISBN: 978-3-540-95884-0
Appears in Collections:Computer Science
Dept of Computer Science Research Papers

Files in This Item:

File Description SizeFormat
wmc9drg.pdf455.37 kBAdobe PDFView/Open

Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.