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Title: Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay
Authors: Miller, D
Wheals, BB
Beresford, NA
Sumpter, JP
Keywords: Estrogenic activity
Phenolic additives
Recombinant yeast assay
Publication Date: 2001
Publisher: National Institute of Environmental Health Sciences (NIEHS)
Citation: Environmental Health Perspectives 109(2): 133 - 138, Feb 2001
Abstract: We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17 beta -estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17<beta>-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.
Description: Copyright @ 2001 Environmental Health Perspectives
Sponsorship: This work was supported in part under contract with the U.K. Department of Trade and Industry as part of the Government Chemist Programme.
ISSN: 0091-6765
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