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http://bura.brunel.ac.uk/handle/2438/10863
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DC Field | Value | Language |
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dc.contributor.author | Jaume, M | - |
dc.contributor.author | Yip, MS | - |
dc.contributor.author | Kam, YW | - |
dc.contributor.author | Cheung, CY | - |
dc.contributor.author | Kien, F | - |
dc.contributor.author | Roberts, A | - |
dc.contributor.author | Li, PH | - |
dc.contributor.author | Dutry, I | - |
dc.contributor.author | Escriou, N | - |
dc.contributor.author | Daeron, M | - |
dc.contributor.author | Bruzzone, R | - |
dc.contributor.author | Subbarao, K | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Nal, B | - |
dc.contributor.author | Altmeyer, R | - |
dc.date.accessioned | 2015-05-14T12:10:44Z | - |
dc.date.available | 2012 | - |
dc.date.available | 2015-05-14T12:10:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Hong Kong Medical Journal, 2012, 18 (SUPP2), pp. 31 - 36 | en_US |
dc.identifier.issn | 1024-2708 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/10863 | - |
dc.description.abstract | 1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2. Antibody-mediated enhancement of SARS-CoV infection with anti-SARS-CoV Spike immune-serum was observed in vitro. 3. Antibody-mediated infection of SARS-CoV triggers entry into human haematopoietic cells via an FcγR-dependent and ACE2-, pH-, cysteine-protease-independent pathways. 4. The antibody-mediated enhancement phenomenon is not a mandatory component of the humoral immune response elicited by SARS vaccines, as pure neutralising antibody only could be obtained. 5. Occurrence of immune-mediated enhancement of SARS-CoV infection raises safety concerns regarding the use of SARS-CoV vaccine in humans and enables new ways to investigate SARS pathogenesis (tropism and immune response deregulation). | en_US |
dc.format.extent | 31 - 36 | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.subject | SARS-CoV | en_US |
dc.subject | Vaccine | en_US |
dc.subject | Antibody | en_US |
dc.subject | Spike-protein trimers | en_US |
dc.subject | triSpike | en_US |
dc.subject | Human haematopoietic cells | en_US |
dc.title | SARS CoV subunit vaccine: Antibodymediated neutralisation and enhancement | en_US |
dc.type | Article | en_US |
dc.relation.isPartOf | Hong Kong Medical Journal | - |
pubs.issue | SUPP2 | - |
pubs.issue | SUPP2 | - |
pubs.volume | 18 | - |
pubs.volume | 18 | - |
Appears in Collections: | Dept of Electronic and Electrical Engineering Research Papers |
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FullText.pdf | 431.56 kB | Adobe PDF | View/Open |
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