Background: This case-report characterized the respiratory, cardiovascular, and nutritional/gastrointestinal (GI) responses of a trained individual to a novel ultra-endurance exercise challenge. Case Presentation: A male athlete (age 45 years; V˙V˙O2max 54.0 mL⋅kg-1⋅min-1) summited 100 mountains on foot&#...

PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely un-known. Here we show that PARK2is altered in over a third of all human cancers, and its depletion results in enhanced ph...

This article provides a critical analysis of the law of police entrapment and proposes a new foundation for this law. The article shows that the ‘shift of scene’ assumption underlies existing and proposed legal tests for the legitimacy of entrapment. According to this assumption,&#...

Ultrasonic processing (USP) during direct-chill (DC) casting of light metal alloys is typically applied in the sump of a billet. This approach, though successful for structure refinement and modification, has two main drawbacks: (a) mixture of mechanisms that rely heavily on dendrite fr...

Piston Al-Si eutectic alloys are used to produce direct-chill cast billets for subsequent forging. Because of a very complex composition and multi-phase heterogeneous structure, it is necessary to control the formation of primary and eutectic compounds either through alloying or casting cond...