Metabolic characterization of a rare genetic variation within APOC3 and its lipoprotein lipase-independent effects See

Background— Plasma triglyceride levels have been implicated in atherosclerosis and coronary heart disease. Apolipoprotein C-III (APOC3) plays a key role in the hydrolysis of triglyceride-rich lipoproteins to remnant particles by lipoprotein lipase (LPL) and their uptake by the liver. A rare...

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids See

Aims An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between rs10911021 and CHD in T2D, whether rs10911021 was asso...

Forecasting price movements in betting exchanges using Cartesian Genetic Programming and ANN See

Since the introduction of betting exchanges in 2000, there has been increased interest of ways to monetize on the new technology. Betting exchange markets are fairly similar to the financial markets in terms of their operation. Due to the lower market share and newer technolog...

Risk of depression and anxiety in adults with cerebral palsy: A UK-cohort study using GP data See

Importance: Cerebral palsy (CP) is considered a paediatric condition despite most people living into adulthood. Due to this we lack evidence in adults with CP, this includes a paucity of research examining mental health in this population. Objectives: Determine the risk of depress...

How changes in column geometry and packing ratio can increase sample load and throughput by a factor of fifty in Counter-Current Chromatography See

This paper builds on the fact that high aspect ratio rectilinear tubing columns of the same length and outside dimensions can double column efficiency. It demonstrates that further improvements in efficiency can be made by using rectilinear tubing columns with half the wall thickne...

Machine Learning for the prediction of the dynamic behavior of a small scale ORC system See

Dynamic modeling plays a crucial role in the analysis of Organic Rankine Cycle (ORC) systems for waste heat recovery, which deal with a highly unsteady heat source. The efficiency of small scale ORCs (i.e. below 100 kW power output) is low (< 10%). Therefore, it is ...

Green Network Costs of 5G and Beyond, Expectations vs Reality See

—Generally, it has been taken for granted that green technology provides clean and cheap energy, but often without consideration of the costs. In fact, there are many trade offs concurrent with enabling such technology. Accordingly, this paper evaluates and compares the green energy...

Higher education provision and access for early years educators: localised challenges arising from national policy in England See

Much has been written about the sustained attempts by successive governments to professional-ise the early years sector over the past 20 years in England (DfE, 2005, 2013, 2017a, 2017b; Lloyd and Hallet, 2010; Osgood, 2006a, 2009; Urban, 2010). A feature of these policy interventio...

Dynamic stretching is not detrimental to neuromechanical and sensorimotor performance of ankle plantarflexors See