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DC Field | Value | Language |
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dc.contributor.author | Burugapalli, K | - |
dc.contributor.author | Chan, JCY | - |
dc.contributor.author | Kelly, JL | - |
dc.contributor.author | Pandit, AS | - |
dc.date.accessioned | 2016-04-20T10:42:21Z | - |
dc.date.available | 2016-04-20T10:42:21Z | - |
dc.date.issued | 2013-09-17 | - |
dc.identifier.citation | Burugapalli, K. et al. (2014) 'Efficacy of crosslinking on tailoring in vivo biodegradability of fibro-porous decellularized extracellular matrix and restoration of native tissue structure: A quantitative study using stereology methods', Macromolecular Bioscience, 14 (2), pp. 244 - 256. doi: 10.1002/mabi.201300195. | en_US |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/12530 | - |
dc.description.abstract | Cholecyst-derived extracellular matrix (CEM) is a fibro-porous decellularized serosal layer of porcine gall-bladder. CEM loses 90% of its weight at 48 h of in vitro collagenase digestion, but takes two months to be completely resorbed in vivo. Carbodiimide (EDC) crosslinking helps tailoring CEM's in vitro collagenase susceptibility. Here, the efficacy of EDC crosslinking on tailoring in vivo biodegradability of CEM is reported. CEM crosslinked with 0.0005 and 0.0033 × 103 M of EDC/mg that lose 80% and 0% of their weight respectively to in vitro collagenase digestion, were present even after 180 days in vivo. Quantitative histopathology using stereology methods confirmed our qualitative observation that even a tiny degree of crosslinking can significantly prolong the rate of in vivo degradation and removal of CEM. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | en_US |
dc.description.sponsorship | Enterprise Ireland – Technology Development | - |
dc.format.extent | 244 - 256 | - |
dc.format.medium | Print-Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | Copyright © 2014 WILEY-VCH. This is the peer reviewed version of the following article: Burugapalli, K. et al. (2014) 'Efficacy of crosslinking on tailoring in vivo biodegradability of fibro-porous decellularized extracellular matrix and restoration of native tissue structure: A quantitative study using stereology methods', Macromolecular Bioscience, 14 (2), pp. 244 - 256, which has been published in final form at https://doi.org/10.1002/mabi.201300195. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions (see: https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html). | - |
dc.rights.uri | https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html | - |
dc.subject | cholecyst-derived extracellular matrix | en_US |
dc.subject | crosslinking | en_US |
dc.subject | biodegradation | en_US |
dc.subject | stereology | en_US |
dc.subject | tissue-implant interactions | en_US |
dc.title | Efficacy of crosslinking on tailoring in vivo biodegradability of fibro-porous decellularized extracellular matrix and restoration of native tissue structure: A quantitative study using stereology methods | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2013-08-12 | - |
dc.identifier.doi | https://doi.org/10.1002/mabi.201300195 | - |
dc.relation.isPartOf | Macromolecular Bioscience | - |
pubs.issue | 2 | - |
pubs.publication-status | Published | - |
pubs.publication-status | Published | - |
pubs.volume | 14 | - |
dc.identifier.eissn | 1616-5195 | - |
dc.rights.holder | WILEY-VCH | - |
Appears in Collections: | Institute for the Environment |
Files in This Item:
File | Description | Size | Format | |
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Fulltext.pdf | Copyright © 2014 WILEY-VCH. This is the peer reviewed version of the following article: Burugapalli, K. et al. (2014) 'Efficacy of crosslinking on tailoring in vivo biodegradability of fibro-porous decellularized extracellular matrix and restoration of native tissue structure: A quantitative study using stereology methods', Macromolecular Bioscience, 14 (2), pp. 244 - 256, which has been published in final form at https://doi.org/10.1002/mabi.201300195. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions (see: https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html). | 4.77 MB | Adobe PDF | View/Open |
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