Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/15094
Title: Simulation Study of the Effect of Influenza and Influenza Vaccination on Risk of Acquiring Guillain-Barre Syndrome
Authors: Hawken, S
Kwong, JC
Deeks, SL
Crowcroft, NS
McGeer, AJ
Ducharme, R
Campitelli, MA
Coyle, D
Wilson, K
Keywords: Science & Technology;Life Sciences & Biomedicine;Immunology;Infectious Diseases;PRACTICE RESEARCH DATABASE;HEALTH-CARE WORKERS;SEASONAL INFLUENZA;UNITED-KINGDOM;A H1N1;VACCINES;SURVEILLANCE;ASSOCIATION;CANADA;CAMPYLOBACTER
Issue Date: 2015
Publisher: CENTERS DISEASE CONTROL
Citation: EMERGING INFECTIOUS DISEASES, 2015, 21 (2), pp. 224 - 231 (8)
Abstract: It is unclear whether seasonal influenza vaccination results in a net increase or decrease in the risk for Guillain-Barré syndrome (GBS). To assess the effect of seasonal influenza vaccination on the absolute risk of acquiring GBS, we used simulation models and published estimates of age- and sex-specific risks for GBS, influenza incidence, and vaccine effectiveness. For a hypothetical 45-year-old woman and 75-year-old man, excess GBS risk for influenza vaccination versus no vaccination was –0.36/1 million vaccinations (95% credible interval –1.22% to 0.28) and –0.42/1 million vaccinations (95% credible interval, –3.68 to 2.44), respectively. These numbers represent a small absolute reduction in GBS risk with vaccination. Under typical conditions (e.g. influenza incidence rates >5% and vaccine effectiveness >60%), vaccination reduced GBS risk. These findings should strengthen confidence in the safety of influenza vaccine and allow health professionals to better put GBS risk in context when discussing influenza vaccination with patients.
URI: http://bura.brunel.ac.uk/handle/2438/15094
ISSN: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348491400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348491400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
1080-6040
1080-6059
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