Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/16234
Title: Validation of patient-specific cerebral blood flow simulation using transcranial Doppler measurements
Authors: Groen, D
Richardson, RA
Coy, R
Schiller, UD
Chandrashekar, H
Robertson, F
Coveney, PV
Keywords: Lattice-boltzmann;Middle cerebral artery;Computational fluid dynamics;Transcranial doppler
Issue Date: 2018
Publisher: Frontiers Media
Citation: Frontiers in Physiology
Abstract: We present a validation study comparing results from a patient-specific lattice-Boltzmann simulation to transcranial Doppler (TCD) velocity measurements in four different planes of the middle cerebral artery (MCA). As part of the study, we compared simulations using a Newtonian and a Carreau-Yasuda rheology model. We also investigated the viability of using downscaled velocities to reduce the required resolution. Simulations with unscaled velocities predict the maximum flow velocity with an error of less than 9%, independent of the rheology model chosen. The accuracy of the simulation predictions worsens considerably when simulations are run at reduced velocity, as is for example the case when inflow velocities from healthy individuals are used on a vascular model of a stroke patient. Our results demonstrate the importance of using directly measured and patient-specific inflow velocities when simulating blood flow in MCAs. We conclude that localized TCD measurements together with predictive simulations can be used to obtain flow estimates with high fidelity over a larger region, and reduce the need for more invasive flow measurement procedures.
URI: http://bura.brunel.ac.uk/handle/2438/16234
ISSN: 1664-042X
Appears in Collections:Dept of Electronic and Computer Engineering Research Papers

Files in This Item:
File Description SizeFormat 
Fulltext.pdf5.97 MBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.