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http://bura.brunel.ac.uk/handle/2438/17201
Title: | Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography |
Authors: | Dong, Y Lin, H Abolghasemi, V Gan, L Zeitler, JA Shen, Y-C |
Keywords: | coating;optical coherence tomography;imaging method;process analytical technology;tablet |
Issue Date: | 2016 |
Citation: | Journal of Pharmaceutical Sciences, 2017, 106 (2), pp. 546 - 553 |
Abstract: | Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating uniformity without compromising on the achievable axial resolution and imaging depth, we comprehensively examine an algebraic reconstruction technique with OCT to significantly reduce the data required. Specifically, a set of coated pharmaceutical tablets with film coating thickness in the range of 60-100 μm is investigated. Results obtained from performing the reconstruction reveal that only 30% of the acquired data are actually required leading to a faster convergence time and a generally good agreement with benchmark data against the intra-tablet coating uniformity measured with terahertz pulsed imaging technology. |
URI: | http://bura.brunel.ac.uk/handle/2438/17201 |
DOI: | http://dx.doi.org/10.1016/j.xphs.2016.09.021 |
ISSN: | 0022-3549 http://dx.doi.org/10.1016/j.xphs.2016.09.021 |
Appears in Collections: | Dept of Electronic and Electrical Engineering Research Papers |
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