Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/24480
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pisapia, F | - |
dc.contributor.author | Balachandran, W | - |
dc.contributor.author | Rasekh, M | - |
dc.date.accessioned | 2022-04-22T13:40:39Z | - |
dc.date.available | 2022-04-22T13:40:39Z | - |
dc.date.issued | 2022-04-11 | - |
dc.identifier | ORCID iD: Wamadeva Balachandran https://orcid.org/0000-0002-4806-2257 | - |
dc.identifier | ORCID iD: Manoochehr Rasekh https://orcid.org/0000-0002-5465-0215 | - |
dc.identifier | 3829 | - |
dc.identifier.citation | Pisapia, F.; Balachandran, W. and Rasekh, M. (2022) 'Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters', Applied Science, 12, 3829, pp. 1 - 21. doi: 10.3390/app12083829. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/24480 | - |
dc.description.abstract | Copyright © 2022 by the authors. Shear stress, pressure, and flow rate are fluid dynamic parameters that can lead to changes in the morphology, proliferation, function, and survival of many cell types and have a determinant impact on tissue function and viability. Microfluidic devices are promising tools to investigate these parameters and fluid behaviour within different microchannel geometries. This study discusses and analyses different designed microfluidic channel geometries regarding the influence of fluid dynamic parameters on their microenvironment at specified fluidic parameters. The results demonstrate that in the circular microchamber, the velocity and shear stress profiles assume a parabolic shape with a maximum velocity occurring in the centre of the chamber and a minimum velocity at the walls. The longitudinal microchannel shows a uniform velocity and shear stress profile throughout the microchannel. Simulation studies for the two geometries with three parallel microchannels showed that in proximity to the micropillars, the velocity and shear stress profiles decreased. Moreover, the pressure is inversely proportional to the width and directly proportional to the flow rate within the microfluidic channels. The simulations showed that the velocity and wall shear stress indicated different values at different flow rates. It was also found that the width and height of the microfluidic channels could affect both velocity and shear stress profiles, contributing to the control of shear stress. The study has demonstrated strategies to predict and control the effects of these forces and the potential as an alternative to conventional cell culture as well as to recapitulate the cell- and organ-specific microenvironment. | en_US |
dc.description.sponsorship | No funding was received for conducting this study. | - |
dc.format.extent | 1 - 21 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Shear stress | en_US |
dc.subject | Velocity | en_US |
dc.subject | Flow rate | en_US |
dc.subject | Micropillars | en_US |
dc.subject | Microchannels | en_US |
dc.subject | Microfluidic devices | en_US |
dc.title | Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/app12083829 | - |
dc.relation.isPartOf | Applied Sciences | - |
pubs.issue | 8 | - |
pubs.publication-status | Published online | - |
pubs.volume | 12 | - |
dc.identifier.eissn | 2076-3417 | - |
dc.rights.holder | The authors | - |
Appears in Collections: | Dept of Electronic and Electrical Engineering Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 7.96 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License