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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/25655
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dc.contributor.authorGu, W-
dc.contributor.authorKavanagh, JM-
dc.contributor.authorMcClure, DD-
dc.date.accessioned2022-12-19T11:38:41Z-
dc.date.available2022-12-19T11:38:41Z-
dc.date.issued2022-10-12-
dc.identifierORCID iD: Dale McClure https://orcid.org/0000-0001-6790-5179-
dc.identifier1011570-
dc.identifier.citationGu, W., Kavanagh, J.M. and McClure, D.D. (2022) 'A scalable model for EPA and fatty acid production by Phaeodactylum tricornutum', Frontiers in Bioengineering and Biotechnology, 10, 1011570, pp. 1 - 19..doi: 10.3389/fbioe.2022.1011570.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/25655-
dc.descriptionData availability statement: The data underpinning this publication can be accessed from Brunel University London's data repository, Brunelfigshare here under a CCBY licence: https://doi.org/10.17633/rd.brunel.21197263.v1.en_US
dc.description.abstractCopyright © 2022 Gu, Kavanagh and McClure.. Large-scale photoautotrophic production of microalgae has the potential to provide a sustainable supply of omega-3 fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) for human and animal nutrition. This study presents a kinetic model for the EPA-producing microalga Phaeodactylum tricornutum in photoautotrophic conditions, with light and nitrogen being the growth limiting factors. The model was developed using a dataset obtained from bench-scale (5 L) cultures and was successfully validated against pilot-scale (50 L) cultures. This model is the first to predict the biomass and total fatty acid accumulation along with the EPA concentrations in the biomass and total fatty acid fraction for microalgae. The model was used to develop an optimized repeated-batch strategy; implementation of this led to increases in the biomass and EPA productivities of 50 and 20% respectively. This clearly indicates the potential of the model to be used as a tool in the design, optimization and scale-up of microalgal systems for EPA production.en_US
dc.description.sponsorshipAustralian Government Research Training Program Scholarship-
dc.format.extent1 - 19-
dc.format.mediumElectronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherFromtiers Media SAen_US
dc.rightsCopyright © 2022 Gu, Kavanagh and McClure. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectmicroalgaeen_US
dc.subjectmodellingen_US
dc.subjectfatty aciden_US
dc.subjectEPAen_US
dc.subjectphotobioreactoren_US
dc.subjectphaeodactylum tricornutumen_US
dc.titleA scalable model for EPA and fatty acid production by Phaeodactylum tricornutumen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3389/fbioe.2022.1011570-
dc.relation.isPartOfFrontiers in Bioengineering and Biotechnology-
pubs.publication-statusPublished-
pubs.volume10-
dc.identifier.eissn2296-4185-
dc.rights.holderGu, Kavanagh and McClure-
Appears in Collections:Dept of Chemical Engineering Research Papers

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