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Title: | Economic evaluation of ASCOT-BPLA: Antihypertensive treatment with an amlodipine-based regimen is cost effective compared with an atenolol-based regimen |
Authors: | Lindgren, P Buxton, MJ Kahan, T Poulter, NR Dahlof, B Sever, PS Wedel, H Jönsson, B |
Keywords: | Hypertension;Primary prevention;Amlodipine;Atenolol;Cost-effectiveness |
Issue Date: | 2008 |
Publisher: | British Medical Journals Publishing Group Ltd & British Cardiovascular Society |
Citation: | Heart 94: e4, 2008 |
Abstract: | Objective: To compare the cost effectiveness of an amlodipine-based strategy and an atenolol-based strategy in the treatment of hypertension in the UK and Sweden.Design: A prospective, randomised trial complemented with a Markov model to assess long-term costs and health effects.Setting: Primary care.Patients: Patients with moderate hypertension and three or more additional risk factors.Interventions: Amlodipine 5-10 mg with perindopril 4 8 mg added as needed or atenolol 50-100 mg with bendroflumethiazide 1.25-2.5 mg and potassium added as neededMain outcome measures: Cost per cardiovascular event and procedure avoided, and cost per quality-adjusted life-year gained.Results: In the UK, the cost to avoid one cardiovascular event or procedure would be (sic)18 965, and the cost to gain one quality-adjusted life-year would be (sic)21 875. The corresponding figures for Sweden were (sic)13 210 and (sic) 856.Conclusions: Compared with the thresholds applied by NICE and in the Swedish National Board of Health and Welfare's Guidelines for Cardiac Care, an amlodipine-based regimen is cost effective for the treatment of hypertension compared with an atenolol- based regimen in the population studied. |
Description: | Copyright © 2010 BMJ Publishing Group Ltd & British Cardiovascular Society All rights reserved. |
URI: | http://heart.bmj.com/content/94/2/e4.full http://bura.brunel.ac.uk/handle/2438/4586 |
DOI: | http://dx.doi.org/10.1136/hrt.2007.127217 |
ISSN: | 1355-6037 |
Appears in Collections: | Health Economics Research Group (HERG) |
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