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Title: Deformability of red blood cells affects their velocity in deterministic lateral displacement devices
Authors: Krüger, T
Holmes, D
Coveney, PV
4th Micro and Nano Flows Conference (MNF2014)
Keywords: Deterministic lateral displacement;Red blood cells;Deformability;Particle separation
Issue Date: 2014
Publisher: Brunel University London
Citation: 4th Micro and Nano Flows Conference, University College London, UK, 7-10 September 2014, Editors CS König, TG Karayiannis and S. Balabani
Series/Report no.: ID 53
Abstract: Recent years have witnessed a strong increase of interest in mechanical particle separation in structured microfluidic devices. Particular examples are enrichment of rare cells in blood (e.g. cancer cells) or separation of complex mixtures of suspended particles. In many cases, particles are separated based on their size, for example white and red blood cells (RBCs). A less common idea is deformability-based sorting of particles of the same size – an approach relevant for malaria detection where the infected RBCs are usually more rigid than their healthy counterparts. We have recently shown that the trajectories of RBCs in deterministic lateral displacement devices strongly depend on their rigidity. In the present article, we investigate – via computer simulations based on the immersed-boundary, lattice-Boltzmann and finite-element methods – the RBC velocity and show that it is significantly affected by the cells’ deformability.
Description: This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community,
ISBN: 978-1-908549-16-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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