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Title: Characterisation of the mechanobiology of stents in vitro
Authors: Boldock, L
Poitevin, C
Casbolt, H
Hsiao, S
Cevans, P
Perrault, C
4th Micro and Nano Flows Conference (MNF2014)
Keywords: Flow mechanics;Shear stress;In vitro assay;Stent;Cardiovascular disease
Issue Date: 2014
Publisher: Brunel University London
Citation: 4th Micro and Nano Flows Conference, University College London, UK, 7-10 September 2014, Editors CS König, TG Karayiannis and S. Balabani
Series/Report no.: ID 193
Abstract: Long-term efficacy of percutaneous coronary intervention (PCI) to treat coronary heart disease is hampered by incidence of in-stent restenosis (ISR). The regrowth of a healthy endothelial layer post-treatment, a key factor in successful vascular repair, has been shown to be affected by the high sensitivity of endothelial cells (EC) to shear stress. Characterisation of stented artery haemodynamics is required to understand the response of EC to complex flow and shear stress patterns induced by stent structure. A device for the in vitro study of coronary stents has been developed and fabricated in polydimethylsiloxane (PDMS). Balloon-mounted cobalt-chromium stents have been successfully deployed, and particle tracking has been employed to obtain streamlines under low flow rate. High-resolution flow-patterns can be imaged, and complemented with in silico analysis from μCT data. The device allows for the seeding of EC, and sustained exposure to shear stress. EC response can be investigated by comparing real-time footage of cellular migration and proliferation to the haemodynamics of the specific region.
Description: This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community,
ISBN: 978-1-908549-16-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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