Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/9891
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thompson, SG | - |
dc.contributor.author | Ashton, HA | - |
dc.contributor.author | Gao, L | - |
dc.contributor.author | Buxton, MJ | - |
dc.contributor.author | Scott, RAP | - |
dc.date.accessioned | 2015-01-21T15:24:32Z | - |
dc.date.available | 2012 | - |
dc.date.available | 2015-01-21T15:24:32Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | British Journal of Surgery, 2012 | en_US |
dc.identifier.issn | 1365-2168 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/bjs.8897/abstract | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/9891 | - |
dc.description.abstract | Background: The long-term effects of abdominal aortic aneurysm (AAA) screening were investigated in extended follow-up from the UK Multicentre Aneurysm Screening Study (MASS) randomized trial. Methods: A population-based sample ofmen aged 65–74 years were randomized individually to invitation to ultrasound screening (invited group) or to a control group not offered screening. Patients with an AAA (3·0 cm or larger) detected at screening underwent surveillance and were offered surgery after predefined criteria had been met. Cause-specific mortality data were analysed using Cox regression. Results: Some 67 770 men were enrolled in the study. Over 13 years, there were 224 AAA-related deaths in the invited group and 381 in the control group, a 42 (95 per cent confidence interval 31 to 51) per cent reduction. There was no evidence of effect on other causes of death, but there was an overall reduction in all-cause mortality of 3 (1 to 5) per cent. The degree of benefit seen in earlier years of follow-up was slightly diminished by the occurrence of AAA ruptures in those with an aorta originally screened normal. About half of these ruptures had a baseline aortic diameter in the range 2·5–2·9 cm. It was estimated that 216 men need to be invited to screening to save one death over the next 13 years. Conclusion: Screening resulted in a reduction in all-cause mortality, and the benefit in AAA-related mortality continued to accumulate throughout follow-up. Registration number: ISRCTN37381646 (http://www.controlled-trials.com). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley Online Library | en_US |
dc.subject | Abdominal aortic aneurysm (AAA) | en_US |
dc.subject | UK Multicentre Aneurysm Screening Study (MASS) | en_US |
dc.subject | Long-term effects | en_US |
dc.title | Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bjs.8897 | - |
dc.relation.isPartOf | British Journal of Surgery | - |
dc.relation.isPartOf | British Journal of Surgery | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Health Economics | - |
pubs.organisational-data | /Brunel/Specialist Centres | - |
pubs.organisational-data | /Brunel/Specialist Centres/HERG | - |
Appears in Collections: | Health Economics Research Group (HERG) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 124.85 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.